Opening of mitochondrial permeability transition pore plays a central role in pathological outcomes in heart attack and other cardiovascular disorders. This proposal intends to determine the new mechanisms of how the permeability transition pore is regulated through calcium and mitochondrial dynamics. The findings from the proposed studies will provide novel insight for developing new therapeutic strategy to ameliorate cardiac ischemia-reperfusion injury and other cardiac pathology.
- National Heart, Lung, and Blood Institute: $456,192.00
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.