PROJECT NARRATIVE Cognitive impairment, and specifically Alzheimer’s disease, represents one of the most significant healthcare problems in the aging population of the United States, and development of effective therapy will be facilitated by understanding its underlying mechanisms. We are studying a protein called synaptobrevin1/VAMP1 and present strong argument for the association of VAMP1 to Alzheimer’s disease, which has public health relevance. After completion of the proposed research we will have developed a new model that offer insight into the mechanism and potential treatment of Alzheimer’s disease leading to dementia in the elderly, thus the proposed research is aligned with the mission of NIH that pertains to developing fundamental knowledge that will help reduce the burdens of human disability.
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