12-Lipoxygenase products increase monocyte: Endothelial interactions

Catherine C. Hedrick, Mary D. Kim, Rama D. Natarajan, Jerry L. Nadler

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


In summary, we suggest that hperglycemia causes upregulation of 12-lipoxygenase activity. The increased production of 12-LO products, 12(S) and 15(S)-HETE, activates monocyte integrins which result in enhanced adhesion of monocytes to endothelium. The binding of monocytes to endothelium is a key early event in development of atherosclerosis. Upregulation of this process by vascular cells exposed to chronic elevations in glucose may be one explanation for the accelerated atherosclerosis observed in patients with Type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)455-460
Number of pages6
JournalAdvances in experimental medicine and biology
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of '12-Lipoxygenase products increase monocyte: Endothelial interactions'. Together they form a unique fingerprint.

Cite this