TY - JOUR
T1 - 12-Lipoxygenase products increase monocyte
T2 - Endothelial interactions
AU - Hedrick, Catherine C.
AU - Kim, Mary D.
AU - Natarajan, Rama D.
AU - Nadler, Jerry L.
PY - 2000
Y1 - 2000
N2 - In summary, we suggest that hperglycemia causes upregulation of 12-lipoxygenase activity. The increased production of 12-LO products, 12(S) and 15(S)-HETE, activates monocyte integrins which result in enhanced adhesion of monocytes to endothelium. The binding of monocytes to endothelium is a key early event in development of atherosclerosis. Upregulation of this process by vascular cells exposed to chronic elevations in glucose may be one explanation for the accelerated atherosclerosis observed in patients with Type 2 diabetes.
AB - In summary, we suggest that hperglycemia causes upregulation of 12-lipoxygenase activity. The increased production of 12-LO products, 12(S) and 15(S)-HETE, activates monocyte integrins which result in enhanced adhesion of monocytes to endothelium. The binding of monocytes to endothelium is a key early event in development of atherosclerosis. Upregulation of this process by vascular cells exposed to chronic elevations in glucose may be one explanation for the accelerated atherosclerosis observed in patients with Type 2 diabetes.
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M3 - Article
C2 - 10667368
AN - SCOPUS:0034465046
SN - 0065-2598
VL - 469
SP - 455
EP - 460
JO - Advances in experimental medicine and biology
JF - Advances in experimental medicine and biology
ER -
