TY - JOUR
T1 - A case of squamous cell carcinoma arising in a giant porokeratosis previously diagnosed as psoriasis
AU - Aitkens, Lorry
AU - Byrne, Joel
AU - Jennings-Dover, Charay
AU - Potter, Kathryn Anne
N1 - Publisher Copyright:
© Copyright: the Author(s), 2023.
PY - 2023
Y1 - 2023
N2 - Porokeratosis (PK) is a disorder of keratinization with a clinical presentation of an atrophic center surrounded by a hyperkeratotic border. Lesions of porokeratosis carry a risk of malignant transformation with giant porokeratosis (GPK) being a high-risk variant. We report a case in which a single, large, erythematous, scaly plaque in an immunocompromised patient showed initial histopathological features consistent with psoriasis and subsequent histological features consistent with GPK. This plaque underwent malignant transformation to squamous cell carcinoma on three occasions. This case highlights that specimens taken from central portions of porokeratosis may resemble a variety of dermatoses histologically, including psoriasis, resulting in misdiagnosis as seen in our patient. When a patient presents with a diagnosis previously made that isn’t responding to therapy as expected, repeat biopsy is appropriate.
AB - Porokeratosis (PK) is a disorder of keratinization with a clinical presentation of an atrophic center surrounded by a hyperkeratotic border. Lesions of porokeratosis carry a risk of malignant transformation with giant porokeratosis (GPK) being a high-risk variant. We report a case in which a single, large, erythematous, scaly plaque in an immunocompromised patient showed initial histopathological features consistent with psoriasis and subsequent histological features consistent with GPK. This plaque underwent malignant transformation to squamous cell carcinoma on three occasions. This case highlights that specimens taken from central portions of porokeratosis may resemble a variety of dermatoses histologically, including psoriasis, resulting in misdiagnosis as seen in our patient. When a patient presents with a diagnosis previously made that isn’t responding to therapy as expected, repeat biopsy is appropriate.
KW - giant porokeratosis
KW - porokeratosis
KW - psoriasis
KW - squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85164820359&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85164820359&partnerID=8YFLogxK
U2 - 10.4081/dr.2023.9634
DO - 10.4081/dr.2023.9634
M3 - Article
AN - SCOPUS:85164820359
SN - 2036-7392
VL - 15
JO - Dermatology Reports
JF - Dermatology Reports
IS - 2
M1 - 9634
ER -