Abstract
Chemists are constantly striving for techniques that add dimensions of orthogonality with increased throughput and sample complexity. Ion mobility spectrometry (IM) is a gasphase separation method that adds new dimensions to mass spectrometry (MS). IM separates gas-phase ions based on their collision cross-section and can be coupled with time of-flight (TOF) mass spectrometry to yield a powerful tool used in the identification and characterization of proteins and peptides. A fundamental introduction to IM is presented with a focus on resolution, sensitivity, and orthogonality coupled with TOF-MS.
Original language | English (US) |
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Pages (from-to) | 56-61 |
Number of pages | 6 |
Journal | Journal of Biomolecular Techniques |
Volume | 13 |
Issue number | 2 |
State | Published - Jun 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Biology