A MLC-based inversely optimized 3D spatially fractionated grid radiotherapy technique

Jian Yue Jin; Bo Zhao; Joseph M. Kaminski; Ning Wen; Yimei Huang; John Vender; Indrin J. Chetty

doi:10.1016/j.radonc.2015.07.047

A MLC-based inversely optimized 3D spatially fractionated grid radiotherapy technique

Jian Yue Jin, Bo Zhao, Joseph M. Kaminski, Ning Wen, Yimei Huang, John Vender, Indrin J. Chetty

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

This study presents a MLC-based, 3D grid-therapy technique with characteristics of both 3D-conformal-radiotherapy and grid-therapy. It generates a brachytherapy-like dose distribution, with D50% of 20, 9.8, 5.4 and 2.9-Gy, for the spheres, target, 1 cm-outershell and 2 cm-outershell, respectively. It may provide a strategy to deliver ablative doses to large tumors safely.

Original language	English (US)
Pages (from-to)	483-486
Number of pages	4
Journal	Radiotherapy and Oncology
Volume	117
Issue number	3
DOIs	https://doi.org/10.1016/j.radonc.2015.07.047
State	Published - Dec 1 2015

Keywords

Ablative radiation
Film dosimetry
Grid therapy
Immune-response
Spatially fractionated radiotherapy

ASJC Scopus subject areas

Hematology
Oncology
Radiology Nuclear Medicine and imaging

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10.1016/j.radonc.2015.07.047

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title = "A MLC-based inversely optimized 3D spatially fractionated grid radiotherapy technique",

abstract = "This study presents a MLC-based, 3D grid-therapy technique with characteristics of both 3D-conformal-radiotherapy and grid-therapy. It generates a brachytherapy-like dose distribution, with D50% of 20, 9.8, 5.4 and 2.9-Gy, for the spheres, target, 1 cm-outershell and 2 cm-outershell, respectively. It may provide a strategy to deliver ablative doses to large tumors safely.",

keywords = "Ablative radiation, Film dosimetry, Grid therapy, Immune-response, Spatially fractionated radiotherapy",

author = "Jin, {Jian Yue} and Bo Zhao and Kaminski, {Joseph M.} and Ning Wen and Yimei Huang and John Vender and Chetty, {Indrin J.}",

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T1 - A MLC-based inversely optimized 3D spatially fractionated grid radiotherapy technique

AU - Jin, Jian Yue

AU - Zhao, Bo

AU - Kaminski, Joseph M.

AU - Wen, Ning

AU - Huang, Yimei

AU - Vender, John

AU - Chetty, Indrin J.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - This study presents a MLC-based, 3D grid-therapy technique with characteristics of both 3D-conformal-radiotherapy and grid-therapy. It generates a brachytherapy-like dose distribution, with D50% of 20, 9.8, 5.4 and 2.9-Gy, for the spheres, target, 1 cm-outershell and 2 cm-outershell, respectively. It may provide a strategy to deliver ablative doses to large tumors safely.

AB - This study presents a MLC-based, 3D grid-therapy technique with characteristics of both 3D-conformal-radiotherapy and grid-therapy. It generates a brachytherapy-like dose distribution, with D50% of 20, 9.8, 5.4 and 2.9-Gy, for the spheres, target, 1 cm-outershell and 2 cm-outershell, respectively. It may provide a strategy to deliver ablative doses to large tumors safely.

KW - Ablative radiation

KW - Film dosimetry

KW - Grid therapy

KW - Immune-response

KW - Spatially fractionated radiotherapy

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JO - Radiotherapy and Oncology

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ER -

A MLC-based inversely optimized 3D spatially fractionated grid radiotherapy technique

Abstract

Keywords

ASJC Scopus subject areas

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