Novyǐ klass kardiotonicheskikh steroidov.

A. V. Kamernitskiǐ; I. A. Kutnevich; I. G. Reshetova; E. I. Chernoburova; Boris A Gorshkov; I. A. Gorshkova; I. I. Kapustina

Novyǐ klass kardiotonicheskikh steroidov.

Translated title of the contribution: A new class of cardiotonic steroids

A. V. Kamernitskiǐ, I. A. Kutnevich, I. G. Reshetova, E. I. Chernoburova, Boris A Gorshkov, I. A. Gorshkova, I. I. Kapustina

Pulmonary

Research output: Contribution to journal › Letter › peer-review

Abstract

A series of 23-oxosteroid derivatives have been synthesized and tested for their inhibiting Na+, K(+)-dependent ATPase from rat brain in the 1 x 10(-6)-1 x 10(-4) M concentrations. Natural 23-oxogenins from sea star Asterias amurensis and synthetic monoesters showed the inhibiting activity upto 50-55%. These compounds caused heart contraction in frogs at the level of the known cardiotonic strophanthin G, and inotropic activity on isolated heart of mollusk Spisula sachalinensis.

Translated title of the contribution	A new class of cardiotonic steroids
Original language	Russian
Pages (from-to)	141-143
Number of pages	3
Journal	Bioorganicheskaia khimiia
Volume	17
Issue number	1
State	Published - Jan 1 1991

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "Novyǐ klass kardiotonicheskikh steroidov.",

abstract = "A series of 23-oxosteroid derivatives have been synthesized and tested for their inhibiting Na+, K(+)-dependent ATPase from rat brain in the 1 x 10(-6)-1 x 10(-4) M concentrations. Natural 23-oxogenins from sea star Asterias amurensis and synthetic monoesters showed the inhibiting activity upto 50-55%. These compounds caused heart contraction in frogs at the level of the known cardiotonic strophanthin G, and inotropic activity on isolated heart of mollusk Spisula sachalinensis.",

author = "Kamernitskiǐ, {A. V.} and Kutnevich, {I. A.} and Reshetova, {I. G.} and Chernoburova, {E. I.} and Gorshkov, {Boris A} and Gorshkova, {I. A.} and Kapustina, {I. I.}",

year = "1991",

month = jan,

day = "1",

language = "Russian",

volume = "17",

pages = "141--143",

journal = "Bioorganicheskaya Khimiya",

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T1 - Novyǐ klass kardiotonicheskikh steroidov.

AU - Kamernitskiǐ, A. V.

AU - Kutnevich, I. A.

AU - Reshetova, I. G.

AU - Chernoburova, E. I.

AU - Gorshkov, Boris A

AU - Gorshkova, I. A.

AU - Kapustina, I. I.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - A series of 23-oxosteroid derivatives have been synthesized and tested for their inhibiting Na+, K(+)-dependent ATPase from rat brain in the 1 x 10(-6)-1 x 10(-4) M concentrations. Natural 23-oxogenins from sea star Asterias amurensis and synthetic monoesters showed the inhibiting activity upto 50-55%. These compounds caused heart contraction in frogs at the level of the known cardiotonic strophanthin G, and inotropic activity on isolated heart of mollusk Spisula sachalinensis.

AB - A series of 23-oxosteroid derivatives have been synthesized and tested for their inhibiting Na+, K(+)-dependent ATPase from rat brain in the 1 x 10(-6)-1 x 10(-4) M concentrations. Natural 23-oxogenins from sea star Asterias amurensis and synthetic monoesters showed the inhibiting activity upto 50-55%. These compounds caused heart contraction in frogs at the level of the known cardiotonic strophanthin G, and inotropic activity on isolated heart of mollusk Spisula sachalinensis.

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M3 - Letter

C2 - 1648353

AN - SCOPUS:17044447655

SN - 0132-3423

VL - 17

SP - 141

EP - 143

JO - Bioorganicheskaya Khimiya

JF - Bioorganicheskaya Khimiya

IS - 1

ER -

Novyǐ klass kardiotonicheskikh steroidov.

Abstract

ASJC Scopus subject areas

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