TY - GEN
T1 - A noninvasive multimodal sono-contrast NIR spectroscopy system for breast cancer diagnosis
AU - Yan, Kaiguo
AU - Podder, Tarun
AU - Huang, Ke
AU - Yu, Yan
AU - Liao, Lydia
PY - 2010/9/6
Y1 - 2010/9/6
N2 - We have developed a multimodal imaging system that combines three modalities, optical spectroscopy, ultrasonography and acoustic radiation force (ARF) for improving diagnosis of breast cancer based on noninvasive interrogation of vasculature. This paper presents a detailed system design. The safety issues regarding the use of laser and ultrasound have also been addressed in this paper. The maximum exposure to skin for laser was controlled within 0.2 W·cm-2 (ANSI Z136.1); exposure from ARF fields were maintained below the FDA diagnostic limit (0.72 W·cm-2). This multimodal system has the potential to improve tumor detection by deploying ARF to produce a measurable difference in the dynamic behavior of the tissue blood supply environment as interrogated by optical spectroscopy, which was demonstrated to be highly diagnostic in a murine tumor model. Pilot clinical study is being carried out.
AB - We have developed a multimodal imaging system that combines three modalities, optical spectroscopy, ultrasonography and acoustic radiation force (ARF) for improving diagnosis of breast cancer based on noninvasive interrogation of vasculature. This paper presents a detailed system design. The safety issues regarding the use of laser and ultrasound have also been addressed in this paper. The maximum exposure to skin for laser was controlled within 0.2 W·cm-2 (ANSI Z136.1); exposure from ARF fields were maintained below the FDA diagnostic limit (0.72 W·cm-2). This multimodal system has the potential to improve tumor detection by deploying ARF to produce a measurable difference in the dynamic behavior of the tissue blood supply environment as interrogated by optical spectroscopy, which was demonstrated to be highly diagnostic in a murine tumor model. Pilot clinical study is being carried out.
KW - ARF
KW - Breast cancer
KW - Multimodal imaging system
KW - Optical spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=77956140182&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956140182&partnerID=8YFLogxK
U2 - 10.1109/BIBE.2010.55
DO - 10.1109/BIBE.2010.55
M3 - Conference contribution
AN - SCOPUS:77956140182
SN - 9780769540832
T3 - 10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010
SP - 285
EP - 286
BT - 10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010
T2 - 10th IEEE International Conference on Bioinformatics and Bioengineering, BIBE-2010
Y2 - 31 May 2010 through 3 June 2010
ER -
