A nonpolymorphic class I gene in the murine major histocompatibility complex

Andrew L. Mellor, Elisabeth H. Weiss, Michel Kress, Gilbert Jay, Richard A. Flavell

Research output: Contribution to journalArticlepeer-review

103 Scopus citations


DNA sequence analysis of a class I gene (Q10), which maps to the Qa2,3 locus in the C57BL/10 (H-2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library. Exon 5, in particular, has an unusual structure such that a polypeptide product is unlikely to be anchored in the cell membrane. Our findings suggest that the two sequences are derived from allelic class I genes, which are nonpolymorphic, in contrast to H-2K allelic sequences from the same mice, and they may encode liver-specific polypeptides of unknown function. Our previous studies indicate that the Q10 gene is a potential donor gene for the generation of mutations at the H-2K locus by inter-gene transfer of genetic information. Thus the lack of polymorphism in class I genes at the Q10 locus implies either that they are not recipients for such exchanges or that selective pressure prevents the accumulation of mutations in genes at this locus.

Original languageEnglish (US)
Pages (from-to)139-144
Number of pages6
Issue number1
StatePublished - Jan 1984

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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