TY - JOUR
T1 - Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naïve patients with depression
AU - Garcia-Rizo, Clemente
AU - Fernandez-Egea, Emilio
AU - Miller, Brian J
AU - Oliveira, Cristina
AU - Justicia, Azucena
AU - Griffith, Jeffrey K.
AU - Heaphy, Christopher M.
AU - Bernardo, Miguel
AU - Kirkpatrick, Brian
N1 - Funding Information:
Supported in part by Grant RO1 DK069265 from the National Institute of Diabetes and Digestive and Kidney Diseases (Dr. Kirkpatrick), NARSAD (Dr. Fernandez-Egea) and by the Instituto de Salud Carlos III, FEDER, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Government of Catalonia, Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement (2009SGR1295) and by Esther Koplowitz Center-Barcelona (Dr. Bernardo). The views stated in this article represent those of the authors and are not official statements of the National Institute of Diabetes and Digestive and Kidney Diseases or the National Institutes of Health.
PY - 2013/2
Y1 - 2013/2
N2 - Chronic mood disorders have been associated with a shortened telomere, a marker of increased mortality rate and aging, and impaired cellular immunity. However, treatment may confound these relationships. We examined the relationship of glucose tolerance, white blood cell count and telomere length to depression in newly diagnosed, antidepressant-naïve patients. Subjects with major depression (n=15), and matched healthy control subjects (n=70) underwent a two-hour oral glucose tolerance test and evaluation of blood cell count and telomere content. The depression group had significantly higher two-hour glucose concentrations and a lower lymphocyte count than control subjects (respective means [SD] for two-hour glucose were 125.0mg/dL [67.9] vs 84.6 [25.6] (p<.001); for lymphocyte count 2.1×109/L [0.6] vs 2.5×109/L [0.7] p=028). Telomere content was significantly shortened in the depression group (87.9 [7.6]) compared to control subjects (101.0 [14.3]; p<0.01). Abnormal glucose tolerance, lymphopenia and a shortened telomere are present early in the course of depression independently of the confounding effect of antidepressant treatment, supporting the concept of major depression as an accelerated aging disease.
AB - Chronic mood disorders have been associated with a shortened telomere, a marker of increased mortality rate and aging, and impaired cellular immunity. However, treatment may confound these relationships. We examined the relationship of glucose tolerance, white blood cell count and telomere length to depression in newly diagnosed, antidepressant-naïve patients. Subjects with major depression (n=15), and matched healthy control subjects (n=70) underwent a two-hour oral glucose tolerance test and evaluation of blood cell count and telomere content. The depression group had significantly higher two-hour glucose concentrations and a lower lymphocyte count than control subjects (respective means [SD] for two-hour glucose were 125.0mg/dL [67.9] vs 84.6 [25.6] (p<.001); for lymphocyte count 2.1×109/L [0.6] vs 2.5×109/L [0.7] p=028). Telomere content was significantly shortened in the depression group (87.9 [7.6]) compared to control subjects (101.0 [14.3]; p<0.01). Abnormal glucose tolerance, lymphopenia and a shortened telomere are present early in the course of depression independently of the confounding effect of antidepressant treatment, supporting the concept of major depression as an accelerated aging disease.
KW - Accelerated aging
KW - Diabetes mellitus
KW - Drug-naïve
KW - Glucose tolerance
KW - Immunosenescence
KW - Lymphopenia
KW - Major depressive disorder
KW - Telomere
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U2 - 10.1016/j.bbi.2012.11.009
DO - 10.1016/j.bbi.2012.11.009
M3 - Article
C2 - 23207109
AN - SCOPUS:84872203489
SN - 0889-1591
VL - 28
SP - 49
EP - 53
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
ER -