TY - JOUR
T1 - Abnormalities in the response of plasma arginine vasopressin during hypertonic saline infusion in patients with eating disorders
AU - Nishita, J. Ken
AU - Ellinwood, Everett H.
AU - Rockwell, W. J.Kenneth
AU - Kuhn, Cynthia M.
AU - Hoffman, Graham W.
AU - McCall, W. Vaughn
AU - Manepalli, Jothika N.
N1 - Funding Information:
From the Department of Psychology (J.K.N.), San Jose St&e University, San Jose, CA, and the Departments of Psychiauy (E.H.E., W.J.K.R., G.W.H.. W.V.McC., J.N.M.) and Pharmacology (E.H.E., C.M.K.), Duke University Medical Center, Durham, NC. Supported in part by NIH Research Grant RR-30, Division of Research Resources, General Clinical Research Centers Program, MH4221@01, and T32 MH15177, and by the Tom and Sarah Kern Anorexia Nervosa Fund. Address reprint requests to Dr. J. Ken Nishita, Department of Psychology, San Jose State University, San Jose, CA 95192-0120. Preliminary results of this study were presented at the Annual Meeting for the Society of Biological Psychiatry, Chicago, IL, May 1987. Received July 9, 1988; revised September 20, 1988.
PY - 1989/5
Y1 - 1989/5
N2 - We examined the response of plasma arginine vasopressin (pAVP) to intravenous 5% hypertonie saline in patients with anorexia nervosa (AN) and bulimia nervosa (BN). Patients did not differ from controls in their subjective response for the onset of thirst; however, only 5 patients (3 AN and 2 BN) showed pAVP levels that were within the normal range (0.5-11.0 pg/ml) for this test. With the exception of two eating disorder (ED) patients, all others showed some nonlinear irregularities in the pattern of their secretion of pAVP in response to the hypertonic saline infusion. Seven of the ED patients showed an irregular abnormally high pAVP secretion, and three patients showed abnormally low pAVP responses. Both of these pAVP secretion abnormalities occurred in underweight and weight-recovered AN patients, as well as in BN patients. The cause and pathophysiological consequences of these abnormalities remain unresolved.
AB - We examined the response of plasma arginine vasopressin (pAVP) to intravenous 5% hypertonie saline in patients with anorexia nervosa (AN) and bulimia nervosa (BN). Patients did not differ from controls in their subjective response for the onset of thirst; however, only 5 patients (3 AN and 2 BN) showed pAVP levels that were within the normal range (0.5-11.0 pg/ml) for this test. With the exception of two eating disorder (ED) patients, all others showed some nonlinear irregularities in the pattern of their secretion of pAVP in response to the hypertonic saline infusion. Seven of the ED patients showed an irregular abnormally high pAVP secretion, and three patients showed abnormally low pAVP responses. Both of these pAVP secretion abnormalities occurred in underweight and weight-recovered AN patients, as well as in BN patients. The cause and pathophysiological consequences of these abnormalities remain unresolved.
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U2 - 10.1016/0006-3223(89)90009-7
DO - 10.1016/0006-3223(89)90009-7
M3 - Article
C2 - 2541809
AN - SCOPUS:0024340326
SN - 0006-3223
VL - 26
SP - 73
EP - 86
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 1
ER -