Activation of calpain-2 by mediators in pulmonary vascular remodeling of pulmonary arterial hypertension

Medicine & Life Sciences

• Calpain 100%
• Vascular Remodeling 95%
• Pulmonary Arterial Hypertension 95%
• Lung 43%
• Pulmonary Artery 20%
• Smooth Muscle Myocytes 15%
• Platelet-Derived Growth Factor 15%
• Phosphorylation 12%
• Protein Phosphatase 2 11%
• 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 10%
• fostriecin 8%
• Smooth Muscle 7%
• calpastatin 6%
• Collagen 6%
• Ethane 6%
• 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 6%
• Cell Proliferation 5%
• Mitogen-Activated Protein Kinase 3 5%
• Mitogen-Activated Protein Kinase 1 5%
• Endothelin-1 4%
• Esters 4%
• Pulmonary Hypertension 4%
• Serine 4%
• Mass Spectrometry 4%
• Serotonin 3%
• Interleukin-6 3%
• Acids 3%
• Proteins 3%
• Animal Models 3%
• Therapeutics 0%

Chemical Compounds

• Dephosphorylation 50%
• BAPTA 33%
• Protein 33%
• Endothelin-1 30%
• Cell Activity 27%
• Serotonin 22%
• Chelating Agent 19%
• Collagen 19%
• Serine 19%
• Calcium(0) 15%
• Mass Spectrometry 13%
• Ester 12%
• Acid 7%