TY - JOUR
T1 - Acute myeloid leukemia with t(10;11)
T2 - A pathological entity with distinct clinical presentation
AU - DiNardo, Courtney D.
AU - Tang, Guilin
AU - Pemmaraju, Naveen
AU - Wang, Sa A.
AU - Pike, Allison
AU - Garcia-Manero, Guillermo
AU - Cortes, Jorge
AU - Bueso-Ramos, Carlos
AU - Kantarjian, Hagop M.
N1 - Funding Information:
This work was supported in part by the MDACC Support Grant (CCSG) CA016672 .
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015
Y1 - 2015
N2 - t(10;11)(p12;q23) is a rare recurrent translocation involving the mixed lineage leukemia (MLL) gene translocation, most commonly seen in pediatric and young adult acute myeloid leukemia (AML), associated with early morbidity including diffuse intravascular coagulation and tumor lysis syndrome with multiorgan system failure from leukocytosis. With supportive care, first remissions are frequently attained, but patients have a high risk of relapse, extramedullary disease, and poor long-term outcomes. Introduction: Acute myeloid leukemias with MLL rearrangements are frequently associated with myelomonocytic and monoblastic/monocytic morphology, with an increased risk of leukocytosis and leukostasis-related complications. Yet, little is known regarding the clinical presentation of adult AML patients with MLL translocations based on the specific translocation partner. Patients and Methods: Two recent AML cases with t(10;11)(p12;q23) translocations are detailed, with their shared presenting symptoms highlighted, followed by a review of the current literature. Results: The specific t(10;11)(p12;q23) MLL translocation is a rare recurrent translocation partner, most commonly seen in pediatric and young adult AML. A high incidence of early morbidity from leukocytosis-related complications are frequently seen, including diffuse intravascular coagulation and tumor lysis syndrome with multiorgan system failure, even without a true leukocytosis. Conclusion: With prompt therapy and intensive supportive care first remissions are frequently attained, however, patients have a high risk of relapse, extramedullary disease, and poor long-term outcomes.
AB - t(10;11)(p12;q23) is a rare recurrent translocation involving the mixed lineage leukemia (MLL) gene translocation, most commonly seen in pediatric and young adult acute myeloid leukemia (AML), associated with early morbidity including diffuse intravascular coagulation and tumor lysis syndrome with multiorgan system failure from leukocytosis. With supportive care, first remissions are frequently attained, but patients have a high risk of relapse, extramedullary disease, and poor long-term outcomes. Introduction: Acute myeloid leukemias with MLL rearrangements are frequently associated with myelomonocytic and monoblastic/monocytic morphology, with an increased risk of leukocytosis and leukostasis-related complications. Yet, little is known regarding the clinical presentation of adult AML patients with MLL translocations based on the specific translocation partner. Patients and Methods: Two recent AML cases with t(10;11)(p12;q23) translocations are detailed, with their shared presenting symptoms highlighted, followed by a review of the current literature. Results: The specific t(10;11)(p12;q23) MLL translocation is a rare recurrent translocation partner, most commonly seen in pediatric and young adult AML. A high incidence of early morbidity from leukocytosis-related complications are frequently seen, including diffuse intravascular coagulation and tumor lysis syndrome with multiorgan system failure, even without a true leukocytosis. Conclusion: With prompt therapy and intensive supportive care first remissions are frequently attained, however, patients have a high risk of relapse, extramedullary disease, and poor long-term outcomes.
KW - AML
KW - DIC
KW - Leukostasis
KW - MLL
KW - TLS
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U2 - 10.1016/j.clml.2014.06.022
DO - 10.1016/j.clml.2014.06.022
M3 - Article
C2 - 25081372
AN - SCOPUS:84926986352
SN - 2152-2650
VL - 15
SP - 47
EP - 51
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
IS - 1
ER -