Acute oral toxicity of sodium fluoride and monofluorophosphate separately or incombination in rats

Gary M. Whitford; N. L. Birdsong-Whitford; C. Finidori

doi:10.1159/000261252

Acute oral toxicity of sodium fluoride and monofluorophosphate separately or incombination in rats

Gary M. Whitford, N. L. Birdsong-Whitford, C. Finidori

Oral Biology & Dx Sciences

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Fasted Sprague-Dawley male rats were used in three experiments to determine the acute LD50 values of fluoridewhen it was administered intragastrically as NaF, disodium monofluorophosphate (Na₂P0₃F, MFP) orNaF and MFP. Another study was done to examine the relationship between the likelihood of a fatal outcome and peak plasma fluoride concentrations as well as 6-hour AUC values. It was concluded that fatalities due to the acute toxic effects of fluoride were:(1) independent of the chemical form in which it was given; (2) independent of the vehicle (dentifrice or water), and (3) not predictable in terms of a well-defined threshold range of peak plasma fluoride concentrations or AUC values.

Original language	English (US)
Pages (from-to)	121-126
Number of pages	6
Journal	Caries Research
Volume	24
Issue number	2
DOIs	https://doi.org/10.1159/000261252
State	Published - 1990

Keywords

Absorption
Acute toxicity
Bioavailability
Dentifrice
LD<inf>50</inf>
Plasma concentration

ASJC Scopus subject areas

General Dentistry

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10.1159/000261252

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abstract = "Fasted Sprague-Dawley male rats were used in three experiments to determine the acute LD50 values of fluoridewhen it was administered intragastrically as NaF, disodium monofluorophosphate (Na2P03F, MFP) orNaF and MFP. Another study was done to examine the relationship between the likelihood of a fatal outcome and peak plasma fluoride concentrations as well as 6-hour AUC values. It was concluded that fatalities due to the acute toxic effects of fluoride were:(1) independent of the chemical form in which it was given; (2) independent of the vehicle (dentifrice or water), and (3) not predictable in terms of a well-defined threshold range of peak plasma fluoride concentrations or AUC values.",

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T1 - Acute oral toxicity of sodium fluoride and monofluorophosphate separately or incombination in rats

AU - Whitford, Gary M.

AU - Birdsong-Whitford, N. L.

AU - Finidori, C.

PY - 1990

Y1 - 1990

N2 - Fasted Sprague-Dawley male rats were used in three experiments to determine the acute LD50 values of fluoridewhen it was administered intragastrically as NaF, disodium monofluorophosphate (Na2P03F, MFP) orNaF and MFP. Another study was done to examine the relationship between the likelihood of a fatal outcome and peak plasma fluoride concentrations as well as 6-hour AUC values. It was concluded that fatalities due to the acute toxic effects of fluoride were:(1) independent of the chemical form in which it was given; (2) independent of the vehicle (dentifrice or water), and (3) not predictable in terms of a well-defined threshold range of peak plasma fluoride concentrations or AUC values.

AB - Fasted Sprague-Dawley male rats were used in three experiments to determine the acute LD50 values of fluoridewhen it was administered intragastrically as NaF, disodium monofluorophosphate (Na2P03F, MFP) orNaF and MFP. Another study was done to examine the relationship between the likelihood of a fatal outcome and peak plasma fluoride concentrations as well as 6-hour AUC values. It was concluded that fatalities due to the acute toxic effects of fluoride were:(1) independent of the chemical form in which it was given; (2) independent of the vehicle (dentifrice or water), and (3) not predictable in terms of a well-defined threshold range of peak plasma fluoride concentrations or AUC values.

KW - Absorption

KW - Acute toxicity

KW - Bioavailability

KW - Dentifrice

KW - LD<inf>50</inf>

KW - Plasma concentration

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Acute oral toxicity of sodium fluoride and monofluorophosphate separately or incombination in rats

Abstract

Keywords

ASJC Scopus subject areas

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