Adjunctive granulocyte colony-stimulating factor therapy for diabetic foot infections

Kelly S. Reed, Manjunath P. Pai

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


OBJECTIVE: To evaluate the role of granulocyte colony-stimulating factor (G-CSF) as adjunctive therapy for the treatment of diabetic foot infections in non-neutropenic patients. DATA SOURCES: Clinical literature was accessed through MEDLINE (1965-April 2004). Key search terms included G-CSF, infection, and diabetes. In addition, relevant references from primary and secondary article bibliographies were extracted. DATA SYNTHESIS: Three clinical trials evaluating G-CSF for diabetic foot infections were identified. These data demonstrated positive effects of G-CSF on improvement of foot infections and risk of amputations. CONCLUSIONS: Controlled trials are necessary to validate the role of adjunctive G-CSF at reducing amputations in patients with diabetic foot infections.

Original languageEnglish (US)
Pages (from-to)2150-2153
Number of pages4
JournalAnnals of Pharmacotherapy
Issue number12
StatePublished - Dec 2004
Externally publishedYes


  • Diabetic foot infections
  • Granulocyte colony-stimulating factor

ASJC Scopus subject areas

  • Pharmacology (medical)


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