Abstract
OBJECTIVE: To evaluate the role of granulocyte colony-stimulating factor (G-CSF) as adjunctive therapy for the treatment of diabetic foot infections in non-neutropenic patients. DATA SOURCES: Clinical literature was accessed through MEDLINE (1965-April 2004). Key search terms included G-CSF, infection, and diabetes. In addition, relevant references from primary and secondary article bibliographies were extracted. DATA SYNTHESIS: Three clinical trials evaluating G-CSF for diabetic foot infections were identified. These data demonstrated positive effects of G-CSF on improvement of foot infections and risk of amputations. CONCLUSIONS: Controlled trials are necessary to validate the role of adjunctive G-CSF at reducing amputations in patients with diabetic foot infections.
Original language | English (US) |
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Pages (from-to) | 2150-2153 |
Number of pages | 4 |
Journal | Annals of Pharmacotherapy |
Volume | 38 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2004 |
Externally published | Yes |
Keywords
- Diabetic foot infections
- Granulocyte colony-stimulating factor
ASJC Scopus subject areas
- Pharmacology (medical)