TY - JOUR
T1 - Advanced paternal age, mortality, and suicide in the general population
AU - Miller, Brian J
AU - Alaräisänen, Antti
AU - Miettunen, Jouko
AU - Järvelin, Marjo Riitta
AU - Koponen, Hannu
AU - Räsänen, Pirkko
AU - Isohanni, Matti
AU - Kirkpatrick, Brian
PY - 2010/6
Y1 - 2010/6
N2 - Advanced paternal age is a risk factor for adverse health outcomes in the offspring. In a population-based birth cohort from Finland, 10,965 singleton offspring born in 1966 and alive at age 1 were followed to age 39. Hazard ratios were calculated, adjusting for maternal age, gender, paternal social class, and maternal parity. In females but not in males, increasing paternal age was associated with a linear increased risk of suicide (hazard ratio [HR] = 1.13, 95% confidence interval [CI] = 1.04-1.24, p < 0.01) and all-causes mortality (HR = 1.06, 95% CI = 1.01-1.10, p = 0.02). Increasing maternal age was associated with a significantly decreased risk of suicide (HR = 0.93, 95% CI = 0.86-1.00, p = 0.04) and all-causes mortality (HR = 0.96, 95% CI = 0.93-1, p = 0.02) in the entire cohort. For paternal age ≥30, the population attributable risk percentage was 13.7% for all deaths and 7.5% for suicides. Parental age at birth may affect suicide and all-causes mortality risk in the offspring in the general population. The causal pathways and specific disorders associated with this increased mortality are largely unknown.
AB - Advanced paternal age is a risk factor for adverse health outcomes in the offspring. In a population-based birth cohort from Finland, 10,965 singleton offspring born in 1966 and alive at age 1 were followed to age 39. Hazard ratios were calculated, adjusting for maternal age, gender, paternal social class, and maternal parity. In females but not in males, increasing paternal age was associated with a linear increased risk of suicide (hazard ratio [HR] = 1.13, 95% confidence interval [CI] = 1.04-1.24, p < 0.01) and all-causes mortality (HR = 1.06, 95% CI = 1.01-1.10, p = 0.02). Increasing maternal age was associated with a significantly decreased risk of suicide (HR = 0.93, 95% CI = 0.86-1.00, p = 0.04) and all-causes mortality (HR = 0.96, 95% CI = 0.93-1, p = 0.02) in the entire cohort. For paternal age ≥30, the population attributable risk percentage was 13.7% for all deaths and 7.5% for suicides. Parental age at birth may affect suicide and all-causes mortality risk in the offspring in the general population. The causal pathways and specific disorders associated with this increased mortality are largely unknown.
KW - Epidemiology
KW - Gender
KW - Mortality
KW - Paternal age
KW - Suicide
UR - http://www.scopus.com/inward/record.url?scp=77953348695&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953348695&partnerID=8YFLogxK
U2 - 10.1097/NMD.0b013e3181e07d79
DO - 10.1097/NMD.0b013e3181e07d79
M3 - Article
C2 - 20531118
AN - SCOPUS:77953348695
SN - 0022-3018
VL - 198
SP - 404
EP - 411
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
IS - 6
ER -