Aging, immunity and cancer

Claude Sportès; Frances T. Hakim

doi:10.1007/978-1-4020-9063-9_55

Aging, immunity and cancer

Claude Sportès, Frances T. Hakim

Hematology and Oncology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Although the increased incidence of common cancers with age on one hand and immunosenescence on the other are both well documented in animal models and in humans, evidence for a causal link between the two is controversial. It is, therefore, most appropriate to critically consider whether the dysfunctional immune processes occurring with aging may play a contributing role in the increased incidence of cancer with aging. Indeed whether or not immunosenescence plays a significant role could have a determinant impact on devising cancer prevention and/or immunotherapeutic strategies for the presently growing elderly population.

Original language	English (US)
Title of host publication	Handbook on Immunosenescence
Subtitle of host publication	Basic Understanding and Clinical Applications
Publisher	Springer Netherlands
Pages	1119-1138
Number of pages	20
Volume	9781402090639
ISBN (Electronic)	9781402090639
ISBN (Print)	9781402090622
DOIs	https://doi.org/10.1007/978-1-4020-9063-9_55
State	Published - 2009

Keywords

Adoptive immunotherapy
Immuno-editing
Immuno-surveillance
Inflammation
Primary immuno-deficiency

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-4020-9063-9_55

Cite this

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AU - Hakim, Frances T.

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AB - Although the increased incidence of common cancers with age on one hand and immunosenescence on the other are both well documented in animal models and in humans, evidence for a causal link between the two is controversial. It is, therefore, most appropriate to critically consider whether the dysfunctional immune processes occurring with aging may play a contributing role in the increased incidence of cancer with aging. Indeed whether or not immunosenescence plays a significant role could have a determinant impact on devising cancer prevention and/or immunotherapeutic strategies for the presently growing elderly population.

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KW - Inflammation

KW - Primary immuno-deficiency

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ER -

Aging, immunity and cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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