ALSUntangled #70: caffeine

Jessica Hatch; Paul Barkhaus; Benjamin Barnes; Morgan Beauchamp; Michael Benatar; Tulio Bertorini; Robert Bowser; Mark Bromberg; Andrew Brown; Javier Mascias Cadavid; Gregory T. Carter; Nicholas Cole; Jesse Crayle; Mazen Dimachkie; David Ennist; Eva Feldman; Timothy Fullam; Terry Heiman-Patterson; Sartaj Jhooty; Todd Levine; Xiaoyan Li; Isaac Lund; Elise Mallon; Nicholas Maragakis; Christopher McDermott; Gary Pattee; Kaitlyn Pierce; Dylan Ratner; Kim Staats; Paul Wicks; Martina Wiedau; Richard Bedlack

doi:10.1080/21678421.2023.2220742

ALSUntangled #70: caffeine

Jessica Hatch, Paul Barkhaus, Benjamin Barnes, Morgan Beauchamp, Michael Benatar, Tulio Bertorini, Robert Bowser, Mark Bromberg, Andrew Brown, Javier Mascias Cadavid, Gregory T. Carter, Nicholas Cole, Jesse Crayle, Mazen Dimachkie, David Ennist, Eva Feldman, Timothy Fullam, Terry Heiman-Patterson, Sartaj Jhooty, Todd LevineXiaoyan Li, Isaac Lund, Elise Mallon, Nicholas Maragakis, Christopher McDermott, Gary Pattee, Kaitlyn Pierce, Dylan Ratner, Kim Staats, Paul Wicks, Martina Wiedau, Richard Bedlack

Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here, we review caffeine which has plausible mechanisms for slowing ALS progression. However, pre-clinical studies are contradictory, and a large case series showed no relationship between caffeine intake and ALS progression rate. While low doses of caffeine are safe and inexpensive, higher doses can cause serious side effects. At this time, we cannot endorse caffeine as a treatment to slow ALS progression.

Original language	English (US)
Pages (from-to)	766-770
Number of pages	5
Journal	Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Volume	24
Issue number	7-8
DOIs	https://doi.org/10.1080/21678421.2023.2220742
State	Published - 2023

Keywords

Amyotrophic lateral sclerosis (ALS)
adenosine
caffeine
coffee
tea

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1080/21678421.2023.2220742

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Hatch, J., Barkhaus, P., Barnes, B., Beauchamp, M., Benatar, M., Bertorini, T., Bowser, R., Bromberg, M., Brown, A., Mascias Cadavid, J., Carter, G. T., Cole, N., Crayle, J., Dimachkie, M., Ennist, D., Feldman, E., Fullam, T., Heiman-Patterson, T., Jhooty, S., ... Bedlack, R. (2023). ALSUntangled #70: caffeine. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 24(7-8), 766-770. https://doi.org/10.1080/21678421.2023.2220742

Hatch, J, Barkhaus, P, Barnes, B, Beauchamp, M, Benatar, M, Bertorini, T, Bowser, R, Bromberg, M, Brown, A, Mascias Cadavid, J, Carter, GT, Cole, N, Crayle, J, Dimachkie, M, Ennist, D, Feldman, E, Fullam, T, Heiman-Patterson, T, Jhooty, S, Levine, T, Li, X, Lund, I, Mallon, E, Maragakis, N, McDermott, C, Pattee, G, Pierce, K, Ratner, D, Staats, K, Wicks, P, Wiedau, M & Bedlack, R 2023, 'ALSUntangled #70: caffeine', Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, vol. 24, no. 7-8, pp. 766-770. https://doi.org/10.1080/21678421.2023.2220742

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title = "ALSUntangled #70: caffeine",

abstract = "ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here, we review caffeine which has plausible mechanisms for slowing ALS progression. However, pre-clinical studies are contradictory, and a large case series showed no relationship between caffeine intake and ALS progression rate. While low doses of caffeine are safe and inexpensive, higher doses can cause serious side effects. At this time, we cannot endorse caffeine as a treatment to slow ALS progression.",

keywords = "Amyotrophic lateral sclerosis (ALS), adenosine, caffeine, coffee, tea",

author = "Jessica Hatch and Paul Barkhaus and Benjamin Barnes and Morgan Beauchamp and Michael Benatar and Tulio Bertorini and Robert Bowser and Mark Bromberg and Andrew Brown and {Mascias Cadavid}, Javier and Carter, {Gregory T.} and Nicholas Cole and Jesse Crayle and Mazen Dimachkie and David Ennist and Eva Feldman and Timothy Fullam and Terry Heiman-Patterson and Sartaj Jhooty and Todd Levine and Xiaoyan Li and Isaac Lund and Elise Mallon and Nicholas Maragakis and Christopher McDermott and Gary Pattee and Kaitlyn Pierce and Dylan Ratner and Kim Staats and Paul Wicks and Martina Wiedau and Richard Bedlack",

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year = "2023",

doi = "10.1080/21678421.2023.2220742",

language = "English (US)",

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AU - Hatch, Jessica

AU - Barkhaus, Paul

AU - Barnes, Benjamin

AU - Beauchamp, Morgan

AU - Benatar, Michael

AU - Bertorini, Tulio

AU - Bowser, Robert

AU - Bromberg, Mark

AU - Brown, Andrew

AU - Mascias Cadavid, Javier

AU - Carter, Gregory T.

AU - Cole, Nicholas

AU - Crayle, Jesse

AU - Dimachkie, Mazen

AU - Ennist, David

AU - Feldman, Eva

AU - Fullam, Timothy

AU - Heiman-Patterson, Terry

AU - Jhooty, Sartaj

AU - Levine, Todd

AU - Li, Xiaoyan

AU - Lund, Isaac

AU - Mallon, Elise

AU - Maragakis, Nicholas

AU - McDermott, Christopher

AU - Pattee, Gary

AU - Pierce, Kaitlyn

AU - Ratner, Dylan

AU - Staats, Kim

AU - Wicks, Paul

AU - Wiedau, Martina

AU - Bedlack, Richard

PY - 2023

Y1 - 2023

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AB - ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here, we review caffeine which has plausible mechanisms for slowing ALS progression. However, pre-clinical studies are contradictory, and a large case series showed no relationship between caffeine intake and ALS progression rate. While low doses of caffeine are safe and inexpensive, higher doses can cause serious side effects. At this time, we cannot endorse caffeine as a treatment to slow ALS progression.

KW - Amyotrophic lateral sclerosis (ALS)

KW - adenosine

KW - caffeine

KW - coffee

KW - tea

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ALSUntangled #70: caffeine

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Keywords

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