ALSUntangled #73: Lion’s Mane

Maya Muhana; Issac Lund; Mark Bromberg; Paul Wicks; Michael Benatar; Benjamin Barnes; Kaitlyn Pierce; Dylan Ratner; Andrew Brown; Tulio Bertorini; Paul Barkhaus; Greg Carter; Javier Mascias Cadavid; Christopher McDermott; Jonathan D. Glass; Gary Pattee; Carmel Armon; Richard Bedlack; Xiaoyan Li

doi:10.1080/21678421.2023.2296557

ALSUntangled #73: Lion’s Mane

Maya Muhana, Issac Lund, Mark Bromberg, Paul Wicks, Michael Benatar, Benjamin Barnes, Kaitlyn Pierce, Dylan Ratner, Andrew Brown, Tulio Bertorini, Paul Barkhaus, Greg Carter, Javier Mascias Cadavid, Christopher McDermott, Jonathan D. Glass, Gary Pattee, Carmel Armon, Richard Bedlack, Xiaoyan Li

Research output: Contribution to journal › Article › peer-review

Abstract

Lion’s Mane (Hericium erinaceus) has historically been used as traditional medicine in Asia and Europe for its potential benefits in fighting infection and cancer. It has gained interest in the neurodegenerative disease field because of its mechanisms of action; these include anti-inflammation, neuroprotection, and promoting neurite growth demonstrated in various cell and animal models. A very small, double-blind, placebo-controlled trial in patients with mild cognitive impairment showed a temporary improvement in cognitive function; this finding has yet to be replicated. However, there have been no studies in ALS cell or animal models or in humans with ALS. Lion’s Mane appears safe and inexpensive when consumed in powder or capsule, but one anaphylactic case was reported after a patient consumed fresh Lion’s Mane mushroom. Currently, we do not have enough information to support the use of Lion’s Mane for treating ALS. We support further research in ALS disease models and clinical trials to study its efficacy.

Original language	English (US)
Journal	Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
DOIs	https://doi.org/10.1080/21678421.2023.2296557
State	Accepted/In press - 2023
Externally published	Yes

Keywords

ALS
Hericium erinaceus
Lion’s Mane

ASJC Scopus subject areas

Neurology
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/21678421.2023.2296557

Cite this

Muhana, M., Lund, I., Bromberg, M., Wicks, P., Benatar, M., Barnes, B., Pierce, K., Ratner, D., Brown, A., Bertorini, T., Barkhaus, P., Carter, G., Mascias Cadavid, J., McDermott, C., Glass, J. D., Pattee, G., Armon, C., Bedlack, R., & Li, X. (Accepted/In press). ALSUntangled #73: Lion’s Mane. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. https://doi.org/10.1080/21678421.2023.2296557

Muhana, M, Lund, I, Bromberg, M, Wicks, P, Benatar, M, Barnes, B, Pierce, K, Ratner, D, Brown, A, Bertorini, T, Barkhaus, P, Carter, G, Mascias Cadavid, J, McDermott, C, Glass, JD, Pattee, G, Armon, C, Bedlack, R & Li, X 2023, 'ALSUntangled #73: Lion’s Mane', Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. https://doi.org/10.1080/21678421.2023.2296557

@article{ecba5338f79d45cabfc0ea93ef892000,

title = "ALSUntangled #73: Lion{\textquoteright}s Mane",

abstract = "Lion{\textquoteright}s Mane (Hericium erinaceus) has historically been used as traditional medicine in Asia and Europe for its potential benefits in fighting infection and cancer. It has gained interest in the neurodegenerative disease field because of its mechanisms of action; these include anti-inflammation, neuroprotection, and promoting neurite growth demonstrated in various cell and animal models. A very small, double-blind, placebo-controlled trial in patients with mild cognitive impairment showed a temporary improvement in cognitive function; this finding has yet to be replicated. However, there have been no studies in ALS cell or animal models or in humans with ALS. Lion{\textquoteright}s Mane appears safe and inexpensive when consumed in powder or capsule, but one anaphylactic case was reported after a patient consumed fresh Lion{\textquoteright}s Mane mushroom. Currently, we do not have enough information to support the use of Lion{\textquoteright}s Mane for treating ALS. We support further research in ALS disease models and clinical trials to study its efficacy.",

keywords = "ALS, Hericium erinaceus, Lion{\textquoteright}s Mane",

author = "Maya Muhana and Issac Lund and Mark Bromberg and Paul Wicks and Michael Benatar and Benjamin Barnes and Kaitlyn Pierce and Dylan Ratner and Andrew Brown and Tulio Bertorini and Paul Barkhaus and Greg Carter and {Mascias Cadavid}, Javier and Christopher McDermott and Glass, {Jonathan D.} and Gary Pattee and Carmel Armon and Richard Bedlack and Xiaoyan Li",

note = "Publisher Copyright: {\textcopyright} 2023 World Federation of Neurology on behalf of the Research Group on Motor Neuron Diseases.",

year = "2023",

doi = "10.1080/21678421.2023.2296557",

language = "English (US)",

journal = "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration",

issn = "2167-8421",

publisher = "Informa Healthcare",

}

TY - JOUR

T1 - ALSUntangled #73

T2 - Lion’s Mane

AU - Muhana, Maya

AU - Lund, Issac

AU - Bromberg, Mark

AU - Wicks, Paul

AU - Benatar, Michael

AU - Barnes, Benjamin

AU - Pierce, Kaitlyn

AU - Ratner, Dylan

AU - Brown, Andrew

AU - Bertorini, Tulio

AU - Barkhaus, Paul

AU - Carter, Greg

AU - Mascias Cadavid, Javier

AU - McDermott, Christopher

AU - Glass, Jonathan D.

AU - Pattee, Gary

AU - Armon, Carmel

AU - Bedlack, Richard

AU - Li, Xiaoyan

PY - 2023

Y1 - 2023

N2 - Lion’s Mane (Hericium erinaceus) has historically been used as traditional medicine in Asia and Europe for its potential benefits in fighting infection and cancer. It has gained interest in the neurodegenerative disease field because of its mechanisms of action; these include anti-inflammation, neuroprotection, and promoting neurite growth demonstrated in various cell and animal models. A very small, double-blind, placebo-controlled trial in patients with mild cognitive impairment showed a temporary improvement in cognitive function; this finding has yet to be replicated. However, there have been no studies in ALS cell or animal models or in humans with ALS. Lion’s Mane appears safe and inexpensive when consumed in powder or capsule, but one anaphylactic case was reported after a patient consumed fresh Lion’s Mane mushroom. Currently, we do not have enough information to support the use of Lion’s Mane for treating ALS. We support further research in ALS disease models and clinical trials to study its efficacy.

AB - Lion’s Mane (Hericium erinaceus) has historically been used as traditional medicine in Asia and Europe for its potential benefits in fighting infection and cancer. It has gained interest in the neurodegenerative disease field because of its mechanisms of action; these include anti-inflammation, neuroprotection, and promoting neurite growth demonstrated in various cell and animal models. A very small, double-blind, placebo-controlled trial in patients with mild cognitive impairment showed a temporary improvement in cognitive function; this finding has yet to be replicated. However, there have been no studies in ALS cell or animal models or in humans with ALS. Lion’s Mane appears safe and inexpensive when consumed in powder or capsule, but one anaphylactic case was reported after a patient consumed fresh Lion’s Mane mushroom. Currently, we do not have enough information to support the use of Lion’s Mane for treating ALS. We support further research in ALS disease models and clinical trials to study its efficacy.

KW - ALS

KW - Hericium erinaceus

KW - Lion’s Mane

UR - http://www.scopus.com/inward/record.url?scp=85180489256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85180489256&partnerID=8YFLogxK

U2 - 10.1080/21678421.2023.2296557

DO - 10.1080/21678421.2023.2296557

M3 - Article

AN - SCOPUS:85180489256

SN - 2167-8421

JO - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

JF - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

ER -

ALSUntangled #73: Lion’s Mane

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this