Aminoacyl benzotriazolides: Versatile reagents for the preparation of peptides and their mimetics and conjugates

Siva S. Panda; C. Dennis Hall; Eric Scriven; Alan R. Katritzky

Aminoacyl benzotriazolides: Versatile reagents for the preparation of peptides and their mimetics and conjugates

Siva S. Panda, C. Dennis Hall, Eric Scriven, Alan R. Katritzky

Chemistry and Physics

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

N-(Protected α-aminoacyl)benzotriazoles are efficient acylating reagents that offer many advantages in the preparation of peptides and their mimetics and conjugates. Advances in methodology, made possible by these novel reagents, have given rise to solution- and solid-phase preparative techniques for generating complex peptides and peptide conjugates, which are useful in the construction of diverse libraries of building blocks for medicinal chemistry.

Original language	English (US)
Pages (from-to)	43-58
Number of pages	16
Journal	Aldrichimica Acta
Volume	46
Issue number	2
State	Published - 2013

Keywords

Benzotriazole
Conjugates
Coupling reagent
Methodology
Peptide synthesis
Peptidomimetics

ASJC Scopus subject areas

Organic Chemistry

Cite this

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AU - Hall, C. Dennis

AU - Scriven, Eric

AU - Katritzky, Alan R.

PY - 2013

Y1 - 2013

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AB - N-(Protected α-aminoacyl)benzotriazoles are efficient acylating reagents that offer many advantages in the preparation of peptides and their mimetics and conjugates. Advances in methodology, made possible by these novel reagents, have given rise to solution- and solid-phase preparative techniques for generating complex peptides and peptide conjugates, which are useful in the construction of diverse libraries of building blocks for medicinal chemistry.

KW - Benzotriazole

KW - Conjugates

KW - Coupling reagent

KW - Methodology

KW - Peptide synthesis

KW - Peptidomimetics

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Aminoacyl benzotriazolides: Versatile reagents for the preparation of peptides and their mimetics and conjugates

Abstract

Keywords

ASJC Scopus subject areas

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