An eyelid sialoblastoma-like tumor with a sarcomatoid myoepithelial component

Tanuja Shet, Mukta Ramadwar, Suash Sharma, Siddhartha Laskar, Brijesh Arora, Purna Kurkure

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Nonround cell tumors are rare in children and often difficult to diagnose. This article describes an 18-month-old child who presented with a mass on the outer aspect of the left eyelid. This mass was incompletely excised. Histologically, the tumor had nests of basaloid and relatively round cells with immature acinar or ductular structures similar to those seen in a conventional sialoblastoma, but these nests were embedded in a malignant spindle cell stroma. This stroma on immunohistochemistry was marked with S-100 and cytokeratin, which, in combination with the pertinent ultrastructural evidence, indicated a myoepithelial differentiation. Overall histologic features suggested a tumor similar to a sialoblastoma with sarcomatoid transformation of the myoepithelial component, hitherto not described in literature. This tumor probably arose from the palpebral lobe of the lacrimal gland. Postsurgery, the patient received chemotherapy (6 cycles of ifosfamide, vincristine, and doxorubicin hydrochloride [Adriamycin]) and local radiotherapy in view of residual disease. Three months after completion of the treatment (1 year after surgery), the patient is well, without any local disease. Awareness of this unusual histology of sialoblastoma will help in avoiding misdiagnosis and also refine treatment-related issues on this rare tumor.

Original languageEnglish (US)
Pages (from-to)309-314
Number of pages6
JournalPediatric and Developmental Pathology
Issue number4
StatePublished - Mar 22 2007
Externally publishedYes


  • Epithelial
  • Eyelid
  • Myoepithelial
  • Pediatric
  • Sarcoma
  • Sialoblastoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine


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