Angiotensin II signal transduction and the mitogen-activated protein kinase pathway

Jennifer L. Duff, Mario B. Marrero, William G. Paxton, Bernhard Schieffer, Kenneth E. Bernstein, Bradford C. Berk

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


In this review, the angiotensin-II-mediated signal transduction pathways involved in vascular smooth muscle cell growth are discussed. Classical pathways involving phospholipase C and protein kinase C, as well as the mitogen-activated protein kinase pathway, are common signal transduction pathways activated by a variety of growth factors to stimulate cell growth. Besides its vasoconstrictor activity, angiotensin II stimulates hypertrophy of vascular smooth muscle cells and is involved in neointimal proliferation following balloon angioplasty. Understanding angiotensin-II-stimulated signaling events, as well as the crosstalk among signaling pathways, may form the basis for the development of new therapies for hypertension and restenosis.

Original languageEnglish (US)
Pages (from-to)511-517
Number of pages7
JournalCardiovascular Research
Issue number4
StatePublished - Oct 1995


  • Angiotensin II
  • Hypertrophy
  • MAP kinase
  • Protein kinase C
  • Signal transduction
  • Vascular smooth muscle

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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