Angiotensin II signal transduction and the mitogen-activated protein kinase pathway

Jennifer L. Duff; Mario B. Marrero; William G. Paxton; Bernhard Schieffer; Kenneth E. Bernstein; Bradford C. Berk

doi:10.1016/S0008-6363(95)00088-7

Angiotensin II signal transduction and the mitogen-activated protein kinase pathway

Jennifer L. Duff, Mario B. Marrero, William G. Paxton, Bernhard Schieffer, Kenneth E. Bernstein, Bradford C. Berk

Graduate Studies

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

In this review, the angiotensin-II-mediated signal transduction pathways involved in vascular smooth muscle cell growth are discussed. Classical pathways involving phospholipase C and protein kinase C, as well as the mitogen-activated protein kinase pathway, are common signal transduction pathways activated by a variety of growth factors to stimulate cell growth. Besides its vasoconstrictor activity, angiotensin II stimulates hypertrophy of vascular smooth muscle cells and is involved in neointimal proliferation following balloon angioplasty. Understanding angiotensin-II-stimulated signaling events, as well as the crosstalk among signaling pathways, may form the basis for the development of new therapies for hypertension and restenosis.

Original language	English (US)
Pages (from-to)	511-517
Number of pages	7
Journal	Cardiovascular Research
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/S0008-6363(95)00088-7
State	Published - Oct 1995

Keywords

Angiotensin II
Hypertrophy
MAP kinase
Protein kinase C
Signal transduction
Vascular smooth muscle

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1016/S0008-6363(95)00088-7

Cite this

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title = "Angiotensin II signal transduction and the mitogen-activated protein kinase pathway",

abstract = "In this review, the angiotensin-II-mediated signal transduction pathways involved in vascular smooth muscle cell growth are discussed. Classical pathways involving phospholipase C and protein kinase C, as well as the mitogen-activated protein kinase pathway, are common signal transduction pathways activated by a variety of growth factors to stimulate cell growth. Besides its vasoconstrictor activity, angiotensin II stimulates hypertrophy of vascular smooth muscle cells and is involved in neointimal proliferation following balloon angioplasty. Understanding angiotensin-II-stimulated signaling events, as well as the crosstalk among signaling pathways, may form the basis for the development of new therapies for hypertension and restenosis.",

keywords = "Angiotensin II, Hypertrophy, MAP kinase, Protein kinase C, Signal transduction, Vascular smooth muscle",

author = "Duff, {Jennifer L.} and Marrero, {Mario B.} and Paxton, {William G.} and Bernhard Schieffer and Bernstein, {Kenneth E.} and Berk, {Bradford C.}",

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T1 - Angiotensin II signal transduction and the mitogen-activated protein kinase pathway

AU - Duff, Jennifer L.

AU - Marrero, Mario B.

AU - Paxton, William G.

AU - Schieffer, Bernhard

AU - Bernstein, Kenneth E.

AU - Berk, Bradford C.

PY - 1995/10

Y1 - 1995/10

N2 - In this review, the angiotensin-II-mediated signal transduction pathways involved in vascular smooth muscle cell growth are discussed. Classical pathways involving phospholipase C and protein kinase C, as well as the mitogen-activated protein kinase pathway, are common signal transduction pathways activated by a variety of growth factors to stimulate cell growth. Besides its vasoconstrictor activity, angiotensin II stimulates hypertrophy of vascular smooth muscle cells and is involved in neointimal proliferation following balloon angioplasty. Understanding angiotensin-II-stimulated signaling events, as well as the crosstalk among signaling pathways, may form the basis for the development of new therapies for hypertension and restenosis.

AB - In this review, the angiotensin-II-mediated signal transduction pathways involved in vascular smooth muscle cell growth are discussed. Classical pathways involving phospholipase C and protein kinase C, as well as the mitogen-activated protein kinase pathway, are common signal transduction pathways activated by a variety of growth factors to stimulate cell growth. Besides its vasoconstrictor activity, angiotensin II stimulates hypertrophy of vascular smooth muscle cells and is involved in neointimal proliferation following balloon angioplasty. Understanding angiotensin-II-stimulated signaling events, as well as the crosstalk among signaling pathways, may form the basis for the development of new therapies for hypertension and restenosis.

KW - Angiotensin II

KW - Hypertrophy

KW - MAP kinase

KW - Protein kinase C

KW - Signal transduction

KW - Vascular smooth muscle

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Angiotensin II signal transduction and the mitogen-activated protein kinase pathway

Abstract

Keywords

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