Antipsychotic Drugs

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


All antipsychotic drugs decrease dopamine neurotransmission. The conventional neuroleptic drugs block dopamine D2 receptors, leading to a gradual reduction of acute psychotic features and the prevention of relapse; they produce coarse neurological side effects at excessive doses. Clozapine was the first atypical antipsychotic in that it did not produce neurological side effects; it also produced greater therapeutic benefit than did the conventional neuroleptics. The newer atypical antipsychotic drugs add antagonism at type 2 serotonin receptors to D2 antagonism, and produce less neurological side effects; however, some of these drugs produce substantial weight gain, and elevations in lipids and insulin resistance.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd.
Number of pages6
ISBN (Print)9780080450469
StatePublished - Jan 1 2009


  • Antipsychotic drugsAripiprazoleAtypical antipsychotic drugsChlorpromazineClozapineNeurolepticsOlanzapinePerphenazinePsychosisQ uetiapineRisperidoneSchizophreniaZiprasidone

ASJC Scopus subject areas

  • General Neuroscience


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