Antithrombotic activity of Formononetin sodium and its mechanism

Yan Jun Wan, Peng Wei Zhuang, Yan Jun Zhang

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations


    Objective: To investigate the effect of formononetin sodium on thrombus formation and its mechanism. Methods: The inhibitory action of formononetin sodium on the thrombus formation was investigated by the model of ferric chloride-induced carotid artery thrombosis in rats. The antithrombotic mechanism was investigated by platelet aggregation and coagulation tests. Results: Formononetin sodium at high and middle dose could inhibit arterial thrombus formation, ADP, and thrombin-induced platelet aggregation in rats, while prolong bleeding time and APTT in mice (P<0.01). Conclusion: Formononetin sodium has anti-thrombosis effect, and its mechanism may correlate with inhibition of ADP, thrombin-induced platelet aggregation and reduction of the function of endogenous coagulation pathway.

    Original languageEnglish (US)
    Pages (from-to)1355-1358
    Number of pages4
    JournalChinese Journal of New Drugs
    Issue number12
    StatePublished - Jun 30 2016


    • Formononetin sodium
    • Platelet aggregation
    • Thrombus formation

    ASJC Scopus subject areas

    • Pharmacology, Toxicology and Pharmaceutics(all)
    • Pharmacology (medical)


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