Aromatic diamidines as antiparasitic agents

M. N.C. Soeiro, E. M. De Souza, C. E. Stephens, D. W. Boykin

Research output: Contribution to journalReview articlepeer-review

97 Scopus citations


Parasitic infections are widespread in developing countries and frequently associated with immunocompromised patients in developed countries. Consequently, such infections are responsible for a significant amount of human mortality, morbidity and economic hardship. A growing consensus has identified the urgent need for the development of new antiparasitic compounds, mostly due to the large number of drug-resistant parasites and the fact that currently available drugs are expensive, highly toxic, require long treatment regimens and frequently exhibit significantly reduced activity towards certain parasite strains and evolutive stages. In this context, the activity of aromatic diamidines has been explored against a widespread range of microorganisms, and the authors' present aim is to review the current status of chemotherapy with these compounds against human parasitic infections.

Original languageEnglish (US)
Pages (from-to)957-972
Number of pages16
JournalExpert Opinion on Investigational Drugs
Issue number8
StatePublished - Aug 2005
Externally publishedYes


  • Aromatic diamidines
  • Chaga's disease
  • Chemotherapy
  • Leishmania
  • Malaria
  • Parasites
  • Trypanosomes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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