Association between mutations of the follicle-stimulating-hormone receptor and repeated twinning

Ayman Al-Hendy; Oksana Moshynska; Anurag Saxena; Valter Feyles

doi:10.1016/s0140-6736(00)02687-8

Association between mutations of the follicle-stimulating-hormone receptor and repeated twinning

Ayman Al-Hendy, Oksana Moshynska, Anurag Saxena, Valter Feyles

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Follicle-stimulating hormone (FSH) has a role in folliculogenesis and spontaneous twinning. Using the candidate gene approach, we searched for mutations in the gene encoding the FSH receptor in a woman who had given birth to two sets of dizygotic twins without fertility treatment. We identified two linked mutations (Thr307Ala and Asn680Ser) that were closely associated with this phenotype. We suggest that expression of both mutations increases the sensitivity of the receptor to FSH.

Original language	English (US)
Pages (from-to)	914
Number of pages	1
Journal	Lancet
Volume	356
Issue number	9233
DOIs	https://doi.org/10.1016/s0140-6736(00)02687-8
State	Published - Sep 9 2000
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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title = "Association between mutations of the follicle-stimulating-hormone receptor and repeated twinning",

abstract = "Follicle-stimulating hormone (FSH) has a role in folliculogenesis and spontaneous twinning. Using the candidate gene approach, we searched for mutations in the gene encoding the FSH receptor in a woman who had given birth to two sets of dizygotic twins without fertility treatment. We identified two linked mutations (Thr307Ala and Asn680Ser) that were closely associated with this phenotype. We suggest that expression of both mutations increases the sensitivity of the receptor to FSH.",

author = "Ayman Al-Hendy and Oksana Moshynska and Anurag Saxena and Valter Feyles",

note = "Funding Information: This study was supported by a research grant from the college of Medicine, University of Saskatchewan.",

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AU - Al-Hendy, Ayman

AU - Moshynska, Oksana

AU - Saxena, Anurag

AU - Feyles, Valter

N1 - Funding Information: This study was supported by a research grant from the college of Medicine, University of Saskatchewan.

PY - 2000/9/9

Y1 - 2000/9/9

N2 - Follicle-stimulating hormone (FSH) has a role in folliculogenesis and spontaneous twinning. Using the candidate gene approach, we searched for mutations in the gene encoding the FSH receptor in a woman who had given birth to two sets of dizygotic twins without fertility treatment. We identified two linked mutations (Thr307Ala and Asn680Ser) that were closely associated with this phenotype. We suggest that expression of both mutations increases the sensitivity of the receptor to FSH.

AB - Follicle-stimulating hormone (FSH) has a role in folliculogenesis and spontaneous twinning. Using the candidate gene approach, we searched for mutations in the gene encoding the FSH receptor in a woman who had given birth to two sets of dizygotic twins without fertility treatment. We identified two linked mutations (Thr307Ala and Asn680Ser) that were closely associated with this phenotype. We suggest that expression of both mutations increases the sensitivity of the receptor to FSH.

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JO - The Lancet

JF - The Lancet

IS - 9233

ER -

Association between mutations of the follicle-stimulating-hormone receptor and repeated twinning

Abstract

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