Associations between serum total bilirubin, obesity and type 2 diabetes

Yuan Wei; Chaoqun Liu; Fangfang Lai; Shan Dong; Haiyan Chen; Li Chen; Liping Shi; Fengfeng Zhu; Chuangbiao Zhang; Xiuxiu Lv; Shuang Peng; Guang Hao

doi:10.1186/s13098-021-00762-0

Associations between serum total bilirubin, obesity and type 2 diabetes

Yuan Wei, Chaoqun Liu, Fangfang Lai, Shan Dong, Haiyan Chen, Li Chen, Liping Shi, Fengfeng Zhu, Chuangbiao Zhang, Xiuxiu Lv, Shuang Peng, Guang Hao

Research output: Contribution to journal › Article › peer-review

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Abstract

BACKGROUND: This study aims to examine the cross-sectional association between serum total bilirubin (STB) and type 2 diabetes (T2D) risk in the general population, and whether obesity could moderate this association.

METHODS: We used data from the 1999-2018 National Health and Nutrition Examination Surveys (NHANES), including a total of 38,641 US adult participants who were 18 years or older. The STB was classified as the low, moderate, and high groups according to tertiles.

RESULTS: We found that participants with lower STB had a significantly higher risk of T2D than those with moderate (OR = 0.81; 95% CI 0.74, 0.89; P < 0.001) and high (OR = 0.65; 95% CI 0.59, 0.73; P < 0.001) STB. Also, a significant interaction between body mass index (BMI) and STB on T2D was observed (P < 0.001). Stratified analysis showed that low STB was associated with a 20% and 27% decrease of T2D risk for moderate and high STB groups in obese patients, however, these effect estimates were smaller in the population with lower BMI (< 30 kg/m2). Similar associations of STB with glycohemoglobin and insulin resistance were observed.

CONCLUSION: This study suggests that STB is associated with an elevated risk of T2D. More importantly, we reported for the first time that BMI may moderate the association between bilirubin and T2D.

Original language	English (US)
Pages (from-to)	143
Journal	Diabetology and Metabolic Syndrome
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/s13098-021-00762-0
State	Published - Dec 7 2021

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title = "Associations between serum total bilirubin, obesity and type 2 diabetes",

abstract = "BACKGROUND: This study aims to examine the cross-sectional association between serum total bilirubin (STB) and type 2 diabetes (T2D) risk in the general population, and whether obesity could moderate this association.METHODS: We used data from the 1999-2018 National Health and Nutrition Examination Surveys (NHANES), including a total of 38,641 US adult participants who were 18 years or older. The STB was classified as the low, moderate, and high groups according to tertiles.RESULTS: We found that participants with lower STB had a significantly higher risk of T2D than those with moderate (OR = 0.81; 95% CI 0.74, 0.89; P < 0.001) and high (OR = 0.65; 95% CI 0.59, 0.73; P < 0.001) STB. Also, a significant interaction between body mass index (BMI) and STB on T2D was observed (P < 0.001). Stratified analysis showed that low STB was associated with a 20% and 27% decrease of T2D risk for moderate and high STB groups in obese patients, however, these effect estimates were smaller in the population with lower BMI (< 30 kg/m2). Similar associations of STB with glycohemoglobin and insulin resistance were observed.CONCLUSION: This study suggests that STB is associated with an elevated risk of T2D. More importantly, we reported for the first time that BMI may moderate the association between bilirubin and T2D.",

author = "Yuan Wei and Chaoqun Liu and Fangfang Lai and Shan Dong and Haiyan Chen and Li Chen and Liping Shi and Fengfeng Zhu and Chuangbiao Zhang and Xiuxiu Lv and Shuang Peng and Guang Hao",

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T1 - Associations between serum total bilirubin, obesity and type 2 diabetes

AU - Wei, Yuan

AU - Liu, Chaoqun

AU - Lai, Fangfang

AU - Dong, Shan

AU - Chen, Haiyan

AU - Chen, Li

AU - Shi, Liping

AU - Zhu, Fengfeng

AU - Zhang, Chuangbiao

AU - Lv, Xiuxiu

AU - Peng, Shuang

AU - Hao, Guang

PY - 2021/12/7

Y1 - 2021/12/7

N2 - BACKGROUND: This study aims to examine the cross-sectional association between serum total bilirubin (STB) and type 2 diabetes (T2D) risk in the general population, and whether obesity could moderate this association.METHODS: We used data from the 1999-2018 National Health and Nutrition Examination Surveys (NHANES), including a total of 38,641 US adult participants who were 18 years or older. The STB was classified as the low, moderate, and high groups according to tertiles.RESULTS: We found that participants with lower STB had a significantly higher risk of T2D than those with moderate (OR = 0.81; 95% CI 0.74, 0.89; P < 0.001) and high (OR = 0.65; 95% CI 0.59, 0.73; P < 0.001) STB. Also, a significant interaction between body mass index (BMI) and STB on T2D was observed (P < 0.001). Stratified analysis showed that low STB was associated with a 20% and 27% decrease of T2D risk for moderate and high STB groups in obese patients, however, these effect estimates were smaller in the population with lower BMI (< 30 kg/m2). Similar associations of STB with glycohemoglobin and insulin resistance were observed.CONCLUSION: This study suggests that STB is associated with an elevated risk of T2D. More importantly, we reported for the first time that BMI may moderate the association between bilirubin and T2D.

AB - BACKGROUND: This study aims to examine the cross-sectional association between serum total bilirubin (STB) and type 2 diabetes (T2D) risk in the general population, and whether obesity could moderate this association.METHODS: We used data from the 1999-2018 National Health and Nutrition Examination Surveys (NHANES), including a total of 38,641 US adult participants who were 18 years or older. The STB was classified as the low, moderate, and high groups according to tertiles.RESULTS: We found that participants with lower STB had a significantly higher risk of T2D than those with moderate (OR = 0.81; 95% CI 0.74, 0.89; P < 0.001) and high (OR = 0.65; 95% CI 0.59, 0.73; P < 0.001) STB. Also, a significant interaction between body mass index (BMI) and STB on T2D was observed (P < 0.001). Stratified analysis showed that low STB was associated with a 20% and 27% decrease of T2D risk for moderate and high STB groups in obese patients, however, these effect estimates were smaller in the population with lower BMI (< 30 kg/m2). Similar associations of STB with glycohemoglobin and insulin resistance were observed.CONCLUSION: This study suggests that STB is associated with an elevated risk of T2D. More importantly, we reported for the first time that BMI may moderate the association between bilirubin and T2D.

U2 - 10.1186/s13098-021-00762-0

DO - 10.1186/s13098-021-00762-0

M3 - Article

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SN - 1758-5996

VL - 13

SP - 143

JO - Diabetology and Metabolic Syndrome

JF - Diabetology and Metabolic Syndrome

IS - 1

ER -

Associations between serum total bilirubin, obesity and type 2 diabetes

Abstract

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