Baseline intraoperative intact parathyroid hormone levels in parathyroid surgery

William S. Duke, Wilson I. Omesiete, Nathaniel J. Walsh, David J. Terris

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: We sought to evaluate the relationship between the preoperative core-laboratory parathyroid hormone (CL-PTH) level and the baseline intraoperative PTH (IOPTH) level and assess the impact of any differences on clinical decision making in consecutive surgical patients with primary hyperparathyroidism undergoing parathyroidectomy. Methods: The CL-PTH and baseline IOPTH levels were compared. The influence of relying on either the CL-PTH or baseline PTH levels for intraoperative decision making was determined. Results: Data were available for 316 patients. Baseline IOPTH measurements were usually higher than the CL-PTH (247 patients; 78.2%) measurements, with a mean difference of 68.2 pg/mL (P <.001). Using the CL-PTH as a surrogate for the baseline parathyroid hormone (PTH) would have prolonged the operation in 23 patients (7.3%). Conclusion: Baseline point-of-care IOPTH levels were higher than the preoperative CL-PTH levels in >75% of patients undergoing parathyroidectomy. Using the CL-PTH in lieu of an IOPTH baseline value would prolong the operation in some patients.

Original languageEnglish (US)
Pages (from-to)592-597
Number of pages6
JournalHead and Neck
Issue number3
StatePublished - Mar 1 2019


  • baseline
  • intraoperative parathyroid hormone (IOPTH)
  • levels
  • parathyroid
  • surgery

ASJC Scopus subject areas

  • Otorhinolaryngology


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