Basic fibroblast growth factor induces TGF-β release in an isoform and glioma-specific manner

Krishnan M. Dhandapani; Marlene F. Wade; Virendra B. Mahesh; Darrell W. Brann

doi:10.1097/00001756-200202110-00013

Basic fibroblast growth factor induces TGF-β release in an isoform and glioma-specific manner

Krishnan M. Dhandapani, Marlene F. Wade, Virendra B. Mahesh, Darrell W. Brann

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The aim of the current study was to determine whether basic fibroblast growth factor (bFGF), regulates the release of transforming growth factor-β1 (TGF-β1) from C6 glioma cells. The results of the study show that bFGF (2, 5 and 10 ng/ml) dose dependently induced the release of TGF-β1 from C6 glioma cells, with the 10 ng/ml dose inducing a 2- to 3-fold increase of TGF-β1 levels. This effect was evident as early as 6 h following treatment, with maximal levels observed at 18 h. The effect of bFGF was largely on latent TGF-β1, and was isoform specific, as bFGF had no effect onTGF-β2 release. The bFGF effect on TGF-β1 was also glioma specific, as no such stimulatory effect was observed in rat cortical astrocytes.

Original language	English (US)
Pages (from-to)	239-241
Number of pages	3
Journal	NeuroReport
Volume	13
Issue number	2
DOIs	https://doi.org/10.1097/00001756-200202110-00013
State	Published - Feb 11 2002

Keywords

Astrocyte bFGF
C6 cells
Glioma
TGF-β

ASJC Scopus subject areas

General Neuroscience

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10.1097/00001756-200202110-00013

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title = "Basic fibroblast growth factor induces TGF-β release in an isoform and glioma-specific manner",

abstract = "The aim of the current study was to determine whether basic fibroblast growth factor (bFGF), regulates the release of transforming growth factor-β1 (TGF-β1) from C6 glioma cells. The results of the study show that bFGF (2, 5 and 10 ng/ml) dose dependently induced the release of TGF-β1 from C6 glioma cells, with the 10 ng/ml dose inducing a 2- to 3-fold increase of TGF-β1 levels. This effect was evident as early as 6 h following treatment, with maximal levels observed at 18 h. The effect of bFGF was largely on latent TGF-β1, and was isoform specific, as bFGF had no effect onTGF-β2 release. The bFGF effect on TGF-β1 was also glioma specific, as no such stimulatory effect was observed in rat cortical astrocytes.",

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AU - Dhandapani, Krishnan M.

AU - Wade, Marlene F.

AU - Mahesh, Virendra B.

AU - Brann, Darrell W.

PY - 2002/2/11

Y1 - 2002/2/11

N2 - The aim of the current study was to determine whether basic fibroblast growth factor (bFGF), regulates the release of transforming growth factor-β1 (TGF-β1) from C6 glioma cells. The results of the study show that bFGF (2, 5 and 10 ng/ml) dose dependently induced the release of TGF-β1 from C6 glioma cells, with the 10 ng/ml dose inducing a 2- to 3-fold increase of TGF-β1 levels. This effect was evident as early as 6 h following treatment, with maximal levels observed at 18 h. The effect of bFGF was largely on latent TGF-β1, and was isoform specific, as bFGF had no effect onTGF-β2 release. The bFGF effect on TGF-β1 was also glioma specific, as no such stimulatory effect was observed in rat cortical astrocytes.

AB - The aim of the current study was to determine whether basic fibroblast growth factor (bFGF), regulates the release of transforming growth factor-β1 (TGF-β1) from C6 glioma cells. The results of the study show that bFGF (2, 5 and 10 ng/ml) dose dependently induced the release of TGF-β1 from C6 glioma cells, with the 10 ng/ml dose inducing a 2- to 3-fold increase of TGF-β1 levels. This effect was evident as early as 6 h following treatment, with maximal levels observed at 18 h. The effect of bFGF was largely on latent TGF-β1, and was isoform specific, as bFGF had no effect onTGF-β2 release. The bFGF effect on TGF-β1 was also glioma specific, as no such stimulatory effect was observed in rat cortical astrocytes.

KW - Astrocyte bFGF

KW - C6 cells

KW - Glioma

KW - TGF-β

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Basic fibroblast growth factor induces TGF-β release in an isoform and glioma-specific manner

Abstract

Keywords

ASJC Scopus subject areas

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