TY - JOUR
T1 - BDNF-TrkB signaling and neuroprotection in schizophrenia
AU - Pandya, Chirayu D.
AU - Kutiyanawalla, Ammar
AU - Pillai, Anilkumar
N1 - Funding Information:
This work was supported by grant from NIH .
PY - 2013/2
Y1 - 2013/2
N2 - Neurotrophins such as brain-derived neurotropic factor (BDNF), play critical role in neuronal survival, synaptic plasticity and cognitive functions. BDNF is known to mediate its action through various intracellular signaling pathways triggered by activation of tyrosine kinase receptor B (TrkB). Evidence from clinical as well pre-clinical studies indicate alterations in BDNF signaling in schizophrenia. Moreover, several antipsychotic drugs have time-dependent effects on BDNF levels in both schizophrenia subjects and animal models of schizophrenia. Given the emerging interest in neuroplasticity in schizophrenia understanding the neuroprotective and cell survival roles of BDNF signaling will enhance our knowledge of its diverse effects, which may lead to more effective treatments for schizophrenia. This article will present an overview of recent findings on the role of BDNF signaling in the pathophysiology and treatment of schizophrenia, with a special focus on its neuroprotective effects.
AB - Neurotrophins such as brain-derived neurotropic factor (BDNF), play critical role in neuronal survival, synaptic plasticity and cognitive functions. BDNF is known to mediate its action through various intracellular signaling pathways triggered by activation of tyrosine kinase receptor B (TrkB). Evidence from clinical as well pre-clinical studies indicate alterations in BDNF signaling in schizophrenia. Moreover, several antipsychotic drugs have time-dependent effects on BDNF levels in both schizophrenia subjects and animal models of schizophrenia. Given the emerging interest in neuroplasticity in schizophrenia understanding the neuroprotective and cell survival roles of BDNF signaling will enhance our knowledge of its diverse effects, which may lead to more effective treatments for schizophrenia. This article will present an overview of recent findings on the role of BDNF signaling in the pathophysiology and treatment of schizophrenia, with a special focus on its neuroprotective effects.
KW - Antipsychotic
KW - Brain-derived neurotrophic factor (BDNF)
KW - Neuroprotection
KW - Schizophrenia
KW - Tyrosine kinase receptor B (TrkB)
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U2 - 10.1016/j.ajp.2012.08.010
DO - 10.1016/j.ajp.2012.08.010
M3 - Review article
C2 - 23380313
AN - SCOPUS:84873159601
SN - 1876-2018
VL - 6
SP - 22
EP - 28
JO - Asian Journal of Psychiatry
JF - Asian Journal of Psychiatry
IS - 1
ER -