Bile reflux gastropathy and functional dyspepsia

Andrew Lake, Satish S.C. Rao, Sebastian Larion, Helena Spartz, Sravan Kavuri

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background/Aims The pathoetiology of functional dyspepsia remains unclear; one mechanism could be chemical gastropathy from chronic bile reflux. We aim to examine the association of bile reflux gastropathy with functional dyspepsia and identify predisposing factors. Methods In a retrospective study, patients with functional dyspepsia (Rome III) who completed symptom assessment, esophagogastroduodenoscopy, and biopsies were categorized into 3 groups; bile gastropathy (BG), non-bile gastropathy (NBG), and no gastropathy (NG). Demographics, symptoms, endoscopy, and motility data were compared between groups. Multivariate analysis identified clinical factors associated with BG. Results Of 262 patients (77.5% female), 90 had BG, 121 had NBG, and 51 had NG. Baseline demographics were similar, however, patients with BG reported significantly more severe abdominal pain than NBG or NG groups (P = 0.018). Gastric erythema was significantly more common in BG vs NBG groups (P < 0.001). Cholecystectomy was significantly associated (OR, 6.6; P = 0.003) with the presence of gastropathy in BG compared to NBG or NG group. Patients with cholecystectomy had significantly more severe abdominal pain (P < 0.05), gastric erythema (P < 0.03), and gastritis (P < 0.05), and were more likely to be prescribed narcotic medications (P < 0.004) than patients without cholecystectomy. Conclusions Bile reflux gastropathy is associated with functional dyspepsia and causes more severe symptoms. Cholecystectomy predisposes to BG and abnormal pain, and could contribute to the pathogenesis of functional dyspepsia.

Original languageEnglish (US)
Pages (from-to)400-407
Number of pages8
JournalJournal of Neurogastroenterology and Motility
Issue number3
StatePublished - Jul 2021


  • Bile reflux
  • Cholecystectomy
  • Dyspepsia
  • Gastritis

ASJC Scopus subject areas

  • Clinical Neurology
  • Gastroenterology


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