TY - JOUR
T1 - Breast cancer stem cells, cytokine networks, and the tumor microenvironment
AU - Korkaya, Hasan
AU - Liu, Suling
AU - Wicha, Max S.
PY - 2011/10/3
Y1 - 2011/10/3
N2 - Many tumors, including breast cancer, are maintained by a subpopulation of cells that display stem cell properties, mediate metastasis, and contribute to treatment resistance. These cancer stem cells (CSCs) are regulated by complex interactions with the components of the tumor microenvironment - including mesenchymal stem cells, adipocytes, tumor associated fibroblasts, endothelial cells, and immune cells - through networks of cytokines and growth factors. Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development.
AB - Many tumors, including breast cancer, are maintained by a subpopulation of cells that display stem cell properties, mediate metastasis, and contribute to treatment resistance. These cancer stem cells (CSCs) are regulated by complex interactions with the components of the tumor microenvironment - including mesenchymal stem cells, adipocytes, tumor associated fibroblasts, endothelial cells, and immune cells - through networks of cytokines and growth factors. Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development.
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U2 - 10.1172/JCI57099
DO - 10.1172/JCI57099
M3 - Review article
C2 - 21965337
AN - SCOPUS:80053401068
SN - 0021-9738
VL - 121
SP - 3804
EP - 3809
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 10
ER -
