Ca2+, histamine antagonists and relaxation to electrical impulses in dog coronary artery

Robin D. Gantzos; Anthony B. Ebeigbe; R. Clinton Webb

doi:10.1016/0014-2999(83)90508-3

Ca²⁺, histamine antagonists and relaxation to electrical impulses in dog coronary artery

Robin D. Gantzos, Anthony B. Ebeigbe, R. Clinton Webb

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Isolated dog coronary arteries relax in response to electrical stimulation (0.1-8.0 Hz, 9 V, 1.0 ms) following contraction induced by serotonin. Cimetidine, metiamide and ranitidine inhibited this relaxation. The relaxation was not blocked by pyrilamine. Reducing the concentration of Ca⁺ (0.1 mM) decreased the rate of relaxation whereas relaxation was more rapid when the Ca²⁺ concentration was increased (3.2 mM). These results suggest that relaxation to electrical stimulation is modulated by Ca²⁺ and by the H₂-subclass of histamine receptors.

Original language	English (US)
Pages (from-to)	287-291
Number of pages	5
Journal	European Journal of Pharmacology
Volume	89
Issue number	3-4
DOIs	https://doi.org/10.1016/0014-2999(83)90508-3
State	Published - May 6 1983
Externally published	Yes

Keywords

Cimetidine
Coronary smooth muscle
Histamine
Metiamide
Pyrilamine
Ranitidine

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(83)90508-3

Cite this

@article{a2724e689c5b408396725270dd03fd3a,

title = "Ca2+, histamine antagonists and relaxation to electrical impulses in dog coronary artery",

abstract = "Isolated dog coronary arteries relax in response to electrical stimulation (0.1-8.0 Hz, 9 V, 1.0 ms) following contraction induced by serotonin. Cimetidine, metiamide and ranitidine inhibited this relaxation. The relaxation was not blocked by pyrilamine. Reducing the concentration of Ca+ (0.1 mM) decreased the rate of relaxation whereas relaxation was more rapid when the Ca2+ concentration was increased (3.2 mM). These results suggest that relaxation to electrical stimulation is modulated by Ca2+ and by the H2-subclass of histamine receptors.",

keywords = "Cimetidine, Coronary smooth muscle, Histamine, Metiamide, Pyrilamine, Ranitidine",

author = "Gantzos, {Robin D.} and Ebeigbe, {Anthony B.} and {Clinton Webb}, R.",

note = "Funding Information: * Supported by grants from the National Institutes of Health (HL-27020, HL-18575). R.D.G. is the recipient of a Michi-gan Heart Association Student Fellowship. R.C.W. is the recipient of a Research Career Development Award from the National Institutes of Health (HL-00813). A.B.E. is an African Senior Research Scholar (Fulbright Award, Depart-ment of Physiology, University of Benin, Nigeria). ** To whom all correspondence should be addressed: Depart-ment of Physiology, University of Michigan, 7720 Medical Science Building II, Ann Arbor, Michigan 48109, U.S.A.",

year = "1983",

month = may,

day = "6",

doi = "10.1016/0014-2999(83)90508-3",

language = "English (US)",

volume = "89",

pages = "287--291",

journal = "European Journal of Pharmacology",

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TY - JOUR

T1 - Ca2+, histamine antagonists and relaxation to electrical impulses in dog coronary artery

AU - Gantzos, Robin D.

AU - Ebeigbe, Anthony B.

AU - Clinton Webb, R.

N1 - Funding Information: * Supported by grants from the National Institutes of Health (HL-27020, HL-18575). R.D.G. is the recipient of a Michi-gan Heart Association Student Fellowship. R.C.W. is the recipient of a Research Career Development Award from the National Institutes of Health (HL-00813). A.B.E. is an African Senior Research Scholar (Fulbright Award, Depart-ment of Physiology, University of Benin, Nigeria). ** To whom all correspondence should be addressed: Depart-ment of Physiology, University of Michigan, 7720 Medical Science Building II, Ann Arbor, Michigan 48109, U.S.A.

PY - 1983/5/6

Y1 - 1983/5/6

N2 - Isolated dog coronary arteries relax in response to electrical stimulation (0.1-8.0 Hz, 9 V, 1.0 ms) following contraction induced by serotonin. Cimetidine, metiamide and ranitidine inhibited this relaxation. The relaxation was not blocked by pyrilamine. Reducing the concentration of Ca+ (0.1 mM) decreased the rate of relaxation whereas relaxation was more rapid when the Ca2+ concentration was increased (3.2 mM). These results suggest that relaxation to electrical stimulation is modulated by Ca2+ and by the H2-subclass of histamine receptors.

AB - Isolated dog coronary arteries relax in response to electrical stimulation (0.1-8.0 Hz, 9 V, 1.0 ms) following contraction induced by serotonin. Cimetidine, metiamide and ranitidine inhibited this relaxation. The relaxation was not blocked by pyrilamine. Reducing the concentration of Ca+ (0.1 mM) decreased the rate of relaxation whereas relaxation was more rapid when the Ca2+ concentration was increased (3.2 mM). These results suggest that relaxation to electrical stimulation is modulated by Ca2+ and by the H2-subclass of histamine receptors.

KW - Cimetidine

KW - Coronary smooth muscle

KW - Histamine

KW - Metiamide

KW - Pyrilamine

KW - Ranitidine

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