Catechin as an antioxidant in liver mitochondrial toxicity: Inhibition of tamoxifen-induced protein oxidation and lipid peroxidation

Heena Tabassum, Suhel Parvez, Hasibur Rehman, Basu Dev Banerjee, Sheikh Raisuddin

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Tamoxifen (TAM) is a nonsteroidal triphenylethylene antiestrogenic drug widely used in the treatment and prevention of breast cancer. TAM brings about a collapse of the mitochondrial membrane potential. It acts both as an uncoupling agent and as a powerful inhibitor of mitochondrial electron transport chain. The effect of catechin pretreatment on the mitochondrial toxicity of TAM was studied in liver mitochondria of Swiss albino mice. TAM treatment caused a significant increase in the mitochondrial lipid peroxidation (LPO) and the protein carbonyls (PCs). It also caused a significant increase in superoxide radical production. Pretreatment of mice with catechin (40 mg/kg) showed significant protection as demonstrated by marked attenuation of increased oxidative stress parameters such LPO, PCs, and superoxide production. It also restored the decreased nonenzymatic and enzymatic antioxidants of mitochondria. The inhibitory effect of catechin on TAM-induced oxidative damage suggests that it may have potential benefits in prevention of human diseases where reactive oxygen species have some role as causative agents.

Original languageEnglish (US)
Pages (from-to)110-117
Number of pages8
JournalJournal of Biochemical and Molecular Toxicology
Volume21
Issue number3
DOIs
StatePublished - 2007
Externally publishedYes

Keywords

  • Catechin
  • Lipid peroxidaion
  • Mitochondria
  • Oxidative stress
  • Protein oxidation
  • Tamoxifen

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Toxicology
  • Health, Toxicology and Mutagenesis

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