Catechol-O-methyltransferase-mediated metabolism of 4-hydroxyestradiol inhibits the growth of human renal cancer cells through the apoptotic pathway

Keyphrases

• 4-hydroxyestradiol 100%
• 4-OHE2 41%
• Antiproliferative Activity 8%
• Apoptosis 8%
• Apoptotic Cell Death 8%
• Apoptotic Pathway 100%
• Biological Significance 8%
• Cancer Cell Lines 8%
• Cancer Cell Proliferation 8%
• Cancer Cells 8%
• Cancer Tissue 8%
• Catechol-O-methyltransferase 100%
• Cell Death 8%
• DNA Damage 8%
• Estrogen 16%
• Estrogen Metabolism 8%
• Functional Impact 8%
• GADD45A 41%
• Growth Arrest 8%
• Human Renal Cancer 100%
• Human Renal Cells 16%
• Long-term Exposure 8%
• Metabolic Pathway 8%
• Metabolism 100%
• Methyltransferase Activity 8%
• Oncogenesis 8%
• Overexpressing 8%
• Overexpression 8%
• Renal Cancer 41%
• Renal Cancer Cells 100%
• Renal Cell 8%
• Risk Factors 8%
• RNA-based 8%
• Small Interfering RNA (siRNA) 8%
• Toxic Substances 8%
• Transient Overexpression 8%
• Tumor Development 8%

Pharmacology, Toxicology and Pharmaceutical Science

• 4 Hydroxyestradiol 100%
• 4 Methoxyestradiol 8%
• Carcinogenesis 8%
• Catechol 100%
• Growth Arrest and DNA Damage Inducible Protein 45 8%
• Growth Disorder 8%
• Kidney Cancer 100%
• Long Term Exposure 8%
• Malignant Neoplasm 50%
• Methyltransferase 100%
• Neoplasm 8%
• Small Interfering RNA 8%
• Toxic Substance 8%

Biochemistry, Genetics and Molecular Biology

• Apoptosis 8%
• Cancer Cell 100%
• Carcinogenesis 8%
• Cell Death 8%
• Cell Proliferation 8%
• DNA Damage 8%
• Downregulation 8%
• Estrogen Metabolism 8%
• Growth Arrest and DNA Damage Inducible Protein 45 8%
• Metabolic Pathway 100%
• Metabolite 8%
• O-Methyltransferase 100%
• Small Interfering RNA 8%
• Upregulation 8%