Centrally administered bacterial lipopolysaccharide depresses feeding in rats

Carlos R. Plata-Salamán, Jeffrey P. Borkoski

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Bacterial lipopolysaccharide (LPS) suppresses feeding in rats when administered peripherally in the microgram range. In the present study, the effects of LPS (Escherichia coli serotype 0111:B4) on the central regulation of feeding in rats maintained ad lib was investigated. Intracerebroventricular (ICV) microinfusion of LPS (0.1 to 1000 ng/rat) suppressed the short-term (2-h) and long-term (nightime and total daily) food intakes, dose dependently. Computerized analysis of behavioral patterns demonstrated a significant reduction of meal size during the nighttime, whereas meal frequency and meal duration were also decreased, but not significantly. Water intake and locomotor activity also decreased. Intraperitoneal administration of LPS in doses equivalent to those administered centrally had no effect on food intake. The results suggest that centrally administered LPS acts directly in the central nervous system (CNS) to depress feeding.

Original languageEnglish (US)
Pages (from-to)787-791
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Issue number4
StatePublished - Dec 1993


  • Anorexia
  • Bacterial lipopolysaccharide
  • Behavior
  • Endotoxin
  • Feeding and drinking
  • Food and water intake
  • Immune system
  • Immunomodulator
  • Infection
  • Interleukin
  • Intracerebroventricular administration
  • Meal pattern
  • Nervous system
  • Neuroimmunology
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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