Cerebrovascular complications of diabetes: Focus on cognitive dysfunction

Trevor Hardigan, Rebecca Ward, Adviye Ergul

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations


The incidence of diabetes has more than doubled in the United States in the last 30 years and the global disease rate is projected to double by 2030. Cognitive impairment has been associated with diabetes, worsening quality of life in patients. The structural and functional interaction of neurons with the surrounding vasculature is critical for proper function of the central nervous system including domains involved in learning and memory. Thus, in this review we explore cognitive impairment in patients and experimental models, focusing on links to vascular dysfunction and structural changes. Lastly, we propose a role for the innate immunity-mediated inflammation in neurovascular changes in diabetes.

Original languageEnglish (US)
Pages (from-to)1807-1822
Number of pages16
JournalClinical Science
Issue number20
StatePublished - 2016


  • Cerebral vasculature
  • Cognitive impairment
  • Diabetes
  • Vascular

ASJC Scopus subject areas

  • General Medicine


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