TY - CHAP
T1 - Chapter 6 Cellular mechanisms of long-term potentiation
T2 - Late maintenance
AU - Frey, Uwe
N1 - Funding Information:
I am very grateful to Hansjürgen Matthies, Klaus G. Reymann, John Donahoe, Vivian Dorsel, and Ritchie Brown for their helpful comments on the manuscript. Portions of the recent experiments reported here were supported by the German BMBF, FKZ: 310258A.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 1997
Y1 - 1997
N2 - Hippocampal long-term potential (LTP) is the primary model for investigating mechanisms and processes involved in the establishment of certain forms of explicit memory in the mammalian brain. During the last decade much progress has been made in elucidating the cellular mechanisms underlying the induction and early expression of LTP. In contrast, little is known about the prolonged maintenance of this phenomenon. The sustained duration of LTP, however, is a prerequisite for its postulated role in information storage. In this chapter, I shall focus on results relevant to the prolonged maintenance of LTP, and show that the cellular processes involved in LTP are consistent with those believed to underlie learning and memory formation.
AB - Hippocampal long-term potential (LTP) is the primary model for investigating mechanisms and processes involved in the establishment of certain forms of explicit memory in the mammalian brain. During the last decade much progress has been made in elucidating the cellular mechanisms underlying the induction and early expression of LTP. In contrast, little is known about the prolonged maintenance of this phenomenon. The sustained duration of LTP, however, is a prerequisite for its postulated role in information storage. In this chapter, I shall focus on results relevant to the prolonged maintenance of LTP, and show that the cellular processes involved in LTP are consistent with those believed to underlie learning and memory formation.
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U2 - 10.1016/S0166-4115(97)80092-1
DO - 10.1016/S0166-4115(97)80092-1
M3 - Chapter
AN - SCOPUS:77956759011
T3 - Advances in Psychology
SP - 105
EP - 128
BT - Advances in Psychology
PB - Elsevier
ER -