TY - JOUR
T1 - Chronic myeloid leukemia
T2 - Diagnosis and treatment
AU - Quintás-Cardama, Alfonso
AU - Cortes, Jorge E.
N1 - Funding Information:
Dr Cortes has research grant support from Novartis, BMS, The Vaccine Company, ChemGenex Pharmaceuticals, Ltd, and Breakthrough Therapeutics.
PY - 2006/7
Y1 - 2006/7
N2 - Chronic myeloid leukemia (CML) has become a model in research and management among malignant disorders. Since the discovery of the presence of a unique and constant chromosomal abnormality slightly more than 40 years ago, substantial progress has been made in the understanding of the biology of the disease. This progress has translated into significant improvement in the long-term prognosis of patients with this disease. This change came first with the use of stem cell transplantation and interferon alfa, but recently it has opened the era of melecularly targeted therapies, imatinib, a potent and selective tyrosine kinase inhibitor, may be the best example of our attempts to Identify molecular abnormalities and develop drugs directed specifically at them. Furthermore, the understanding of at least some of the mechanisms of resistance to imatinib has led to rapid development of new agents that may overcome this resistance. The outlook today for patients with CML is much brighter than just a few years ago. It is our hope that this fascinating journey in CML can be replicated in other malignancies. In this article, we review our current understanding of this disease.
AB - Chronic myeloid leukemia (CML) has become a model in research and management among malignant disorders. Since the discovery of the presence of a unique and constant chromosomal abnormality slightly more than 40 years ago, substantial progress has been made in the understanding of the biology of the disease. This progress has translated into significant improvement in the long-term prognosis of patients with this disease. This change came first with the use of stem cell transplantation and interferon alfa, but recently it has opened the era of melecularly targeted therapies, imatinib, a potent and selective tyrosine kinase inhibitor, may be the best example of our attempts to Identify molecular abnormalities and develop drugs directed specifically at them. Furthermore, the understanding of at least some of the mechanisms of resistance to imatinib has led to rapid development of new agents that may overcome this resistance. The outlook today for patients with CML is much brighter than just a few years ago. It is our hope that this fascinating journey in CML can be replicated in other malignancies. In this article, we review our current understanding of this disease.
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U2 - 10.4065/81.7.973
DO - 10.4065/81.7.973
M3 - Article
C2 - 16835977
AN - SCOPUS:33745592518
SN - 0025-6196
VL - 81
SP - 973
EP - 988
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
IS - 7
ER -