Clinical and endocrine studies in menopausal women after estradiol pellet implantation

M. Nagamani, T. J. Lin, P. G. Mcdonough, H. Watatanl, J. C. Mcpherson, V. Mahesh

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Eight patients who required prolonged estrogen replacement therapy were implanted with two 25-mg pellets of estradiol-17β and were followed with serial measurements of serum estradiol, estrone, follicle stimulating hormone, luteinizing hormone, and maturation index of the vaginal smears. There was a significant increase in estrogen levels within 24 hours after pellet implantation, and this level was maintained in physiologic premenopausal range during the rest of the period of followup. Gonadotropins were suppressed to a greater degree in gonadal dysgenesis patients as compared to postmenopausal patients. There was rapid relief of vasomotor symptoms within 4-10 days even though the gonadotropin levels were high. Implantation of 50 mg of estradiol pellets and periodic withdrawal bleeding with a progestational agent seems to he an effective method of long-term replacement therapy.

Original languageEnglish (US)
Pages (from-to)541-547
Number of pages7
JournalObstetrics and gynecology
Issue number5
StatePublished - Nov 1977

ASJC Scopus subject areas

  • Obstetrics and Gynecology


Dive into the research topics of 'Clinical and endocrine studies in menopausal women after estradiol pellet implantation'. Together they form a unique fingerprint.

Cite this