Comparative study of human placental & fetal brain alkaline phosphatase

T. K. Chatterjee, P. Banerjee, S. K. Banerjee, J. J. Ghosh

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Significant alkaline phosphatase activity has been found in human placenta and fetal brain tissues. The enzyme is present in cytosol as well as in microsomal fractions with a relatively higher activity in the latter fraction. The activity of the enzyme in both the tissues shows a progressive increment with gestational age of the tissues; however, the term placental tissues does not register any further increase in the enzyme activity. In contrast to fetal brain, the placental enzyme demonstrates varying degrees of heat-stability depending on the gestational age of the tissue with preponderance after 14 weeks. Both fetal brain and placental enzymes demonstrate a characteristic activation after pre-exposure at pH 5.0; however, after 14 weeks the placental enzyme cannot demonstrate such acid-pH-induced activation. Dialysed enzyme preparation of both the tissues can demonstrate acid-pH-induced activation phenomena only when the pre-exposure is carried out in the presence of inorganic orthophosphate where arsenate acts as an inhibitor.

Original languageEnglish (US)
Pages (from-to)268-272
Number of pages5
JournalIndian Journal of Biochemistry and Biophysics
Issue number5
StatePublished - Dec 1 1979

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry


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