Compounds of IL-6 Receptor Complex during Acute Lung Injury

D. A. Chepurnova, E. V. Samoilova, A. A. Anisimov, A. D. Verin, A. A. Korotaeva

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Soluble receptor of IL-6 (sIL-6R) and antagonist of the receptor complex, soluble glycoprotein 130 (sgp130) mediate opposite effects during inflammation. We measured the levels of these cytokines and their ratio in rat blood on the model of acute lung injury. The injury was modeled by the intratracheal administration of LPS. The levels of sgp130 and sIL-6R increased during the inflammatory process in the injured lungs. The sgp130/sIL-6R ratio increased or decreased depending on the intensity of the inflammatory process. sgp130/sIL-6R ratio might reflect the intensity of inflammation during lung injury.

Original languageEnglish (US)
Pages (from-to)609-611
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Issue number5
StatePublished - Mar 1 2018


  • acute lung injury
  • inflammation
  • sgp130
  • soluble receptor of IL-6

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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