TY - JOUR
T1 - Comprehensive allelotype and genetic analysis of 466 human nervous system tumors
AU - Von Deimling, Andreas
AU - Fimmers, Rolf
AU - Schmidt, Matthias C.
AU - Bender, Bernhard
AU - Fassbender, Frank
AU - Nagel, Judith
AU - Jahnke, Rolf
AU - Kaskel, Peter
AU - Duerr, Eva Maria
AU - Koopmann, Jens
AU - Maintz, David
AU - Steinbeck, Stephanie
AU - Wick, Wolfgang
AU - Platten, Michael
AU - Müller, Daniel J.
AU - Przkora, René
AU - Waha, Andreas
AU - Blümcke, Britta
AU - Wellenreuther, Ruth
AU - Meyer-Puttlitz, Birgit
AU - Schmidt, Ortrud
AU - Mollenhauer, Jan
AU - Poustka, Annemarie
AU - Stangl, Armin P.
AU - Lenartz, Doris
AU - Von Ammon, Klaus
AU - Henson, John W.
AU - Schramm, Johannes
AU - Louis, David N.
AU - Wiestler, Otmar D.
PY - 2000/6
Y1 - 2000/6
N2 - Brain tumors pose a particular challenge to molecular oncology. Many different tumor entities develop in the nervous system and some of them appear to follow distinct pathogenic routes. Molecular genetic alterations have increasingly been reported in nervous system neoplasms. However, a considerable number of affected genes remain to be identified. We present here a comprehensive allelotype analysis of 466 nervous system tumors based on loss of heterozygosity (LOH) studies with 129 microsatellite markers that span the genome. Specific alterations of the EGFR, CDK4, CDKN2A, TP53, DMBTI, NF2, and PTEN genes were analyzed in addition. Our data point to several novel genetic loci associated with brain tumor development, demonstrate relationships between molecular changes and histopathological features, and further expand the concept of molecular tumor variants in neuro-oncology. This catalogue may provide a valuable framework for future studies to delineate molecular pathways in many types of human central nervous system tumors.
AB - Brain tumors pose a particular challenge to molecular oncology. Many different tumor entities develop in the nervous system and some of them appear to follow distinct pathogenic routes. Molecular genetic alterations have increasingly been reported in nervous system neoplasms. However, a considerable number of affected genes remain to be identified. We present here a comprehensive allelotype analysis of 466 nervous system tumors based on loss of heterozygosity (LOH) studies with 129 microsatellite markers that span the genome. Specific alterations of the EGFR, CDK4, CDKN2A, TP53, DMBTI, NF2, and PTEN genes were analyzed in addition. Our data point to several novel genetic loci associated with brain tumor development, demonstrate relationships between molecular changes and histopathological features, and further expand the concept of molecular tumor variants in neuro-oncology. This catalogue may provide a valuable framework for future studies to delineate molecular pathways in many types of human central nervous system tumors.
KW - Allelotype
KW - Brain
KW - Molecular genetics
KW - Mutation
KW - Tumor
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U2 - 10.1093/jnen/59.6.544
DO - 10.1093/jnen/59.6.544
M3 - Article
C2 - 10850867
AN - SCOPUS:0034129892
SN - 0022-3069
VL - 59
SP - 544
EP - 558
JO - Journal of neuropathology and experimental neurology
JF - Journal of neuropathology and experimental neurology
IS - 6
ER -