@inproceedings{cd4d76dbd6944436a9ac2c4d3659c436,
title = "Construction of protein backbone pieces using segmentbased FBCCD and Cryo-EM skeleton",
abstract = "Cryo-Electron Microscopy is a biophysical technique that generates volumetric images of macromolecules. Although it is hard to distinguish the backbone from the density map at medium resolutions such as 5-10{\AA}, the location of major secondary structure traces and the skeleton can be detected from such density maps. We introduce an effective method to construct pieces of backbone conformations for α-helices, β-strands and loops using α-traces, β-traces and skeleton trace that can be detected from a density map. A test of nineteen cases shows that our fragmentbased FBCCD method can quickly build a model that aligns well with a spline trace with a small RMSD from the native.",
keywords = "Density, Electron microscopy, Graph, Loop, Modeling, Protein, Secondary structure, Shortest paths, Structure, Topology, Volume",
author = "{Al Nasr}, Kamal and Jing He",
note = "Publisher Copyright: Copyright {\textcopyright} 2014 ACM.; 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, ACM BCB 2014 ; Conference date: 20-09-2014 Through 23-09-2014",
year = "2014",
month = sep,
day = "20",
doi = "10.1145/2649387.2660838",
language = "English (US)",
series = "ACM BCB 2014 - 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics",
publisher = "Association for Computing Machinery",
pages = "711--716",
booktitle = "ACM BCB 2014 - 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics",
}