TY - JOUR
T1 - Customized compact neutron activation analysis system to quantify manganese (Mn) in bone in vivo
AU - Liu, Yingzi
AU - Mostafaei, Farshad
AU - Sowers, Daniel
AU - Hsieh, Mindy
AU - Zheng, Wei
AU - Nie, Linda H.
N1 - Funding Information:
This work was supported by the National Institute for Occupational Safety and Health (NIOSH) grants 1R21OH010044 and 1R21OH010700; the Purdue University Nuclear Regulatory Commission (NRC) Faculty Development Grant NRC-HQ-11-G-38-0006; and Purdue Bilsland Fellowship.
Publisher Copyright:
© 2017 Institute of Physics and Engineering in Medicine.
PY - 2017/2/7
Y1 - 2017/2/7
N2 - Objective: In the US alone, millions of workers, including over 300 000 welders, are at high risk of occupational manganese (Mn) exposure. Those who have been chronically exposed to excessive amount of Mn can develop severe neurological disorders similar, but not identical, to the idiopathic Parkinson's disease. One challenge of identifing the health effects of Mn exposure is to find a reliable biomarker for exposure assessment, especially for long-term cumulative exposure. Approach: Mn's long biological half-life as well as its relatively high concentration in bone makes bone Mn (BnMn) a potentially valuable biomarker for Mn exposure. Our group has been working on the development of a deuterium-deuterium (D-D)-based neutron generator to quantify Mn in bone in vivo. Main results and significance: In this paper, we report the latest advancements in our system. With a customized hand irradiation assembly, a fully characterized high purity germanium (HPGe) detector system, and an acceptable hand dose of 36 mSv, a detection limit of 0.64g Mn/g bone (ppm) has been achieved.
AB - Objective: In the US alone, millions of workers, including over 300 000 welders, are at high risk of occupational manganese (Mn) exposure. Those who have been chronically exposed to excessive amount of Mn can develop severe neurological disorders similar, but not identical, to the idiopathic Parkinson's disease. One challenge of identifing the health effects of Mn exposure is to find a reliable biomarker for exposure assessment, especially for long-term cumulative exposure. Approach: Mn's long biological half-life as well as its relatively high concentration in bone makes bone Mn (BnMn) a potentially valuable biomarker for Mn exposure. Our group has been working on the development of a deuterium-deuterium (D-D)-based neutron generator to quantify Mn in bone in vivo. Main results and significance: In this paper, we report the latest advancements in our system. With a customized hand irradiation assembly, a fully characterized high purity germanium (HPGe) detector system, and an acceptable hand dose of 36 mSv, a detection limit of 0.64g Mn/g bone (ppm) has been achieved.
KW - MCNP
KW - manganese
KW - neutron activation analysis
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U2 - 10.1088/1361-6579/aa577b
DO - 10.1088/1361-6579/aa577b
M3 - Article
C2 - 28060775
AN - SCOPUS:85014837286
SN - 0967-3334
VL - 38
SP - 452
EP - 465
JO - Physiological Measurement
JF - Physiological Measurement
IS - 3
ER -