CXCR4 in epidermal keratinocytes: Crosstalk within the skin

Wendy B. Bollag, William D. Hill

Research output: Contribution to journalComment/debatepeer-review

21 Scopus citations


In this issue, Takekoshi et al. investigated the role of CXCR4 in IL-23-induced keratinocyte hyperproliferation using an epidermal-specific knockout mouse model and found that CXCR4 limited keratinocyte proliferation. Some reports in the literature support this idea, whereas others contradict it; this disparity may be related to the differential roles of CXCR4 in various cell types or to a recently identified second receptor (CXCR7). Nevertheless, CXCR4 and its ligand SDF-1 have been implicated in skin wound healing, systemic lupus erythematosus, and basal cell carcinoma tumor angiogenesis. Further study is merited.

Original languageEnglish (US)
Pages (from-to)2505-2508
Number of pages4
JournalJournal of Investigative Dermatology
Issue number11
StatePublished - Nov 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology


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