Cytotoxic effects of NaOCl on vital tissue

E. L. Pashley; N. L. Birdsong; K. Bowman; D. H. Pashley

doi:10.1016/S0099-2399(85)80197-7

Cytotoxic effects of NaOCl on vital tissue

E. L. Pashley, N. L. Birdsong, K. Bowman, D. H. Pashley

Oral Biology

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Abstract

The cytotoxicity of various dilutions of sodium hypochlorite was evaluated using three independent biological models. Dilutions as low as 1:1000 caused complete hemolysis of RBC's in vitro. Undiluted and 1:10 dilutions produced moderate to severe irritation to rabbit eyes which healed after 24 to 48 h. Intradermal injections of undiluted, 1:1, 1:2, and 1:4 dilutions of NaOCl produced skin ulcerations following intradermal injections. Although the use of 5% NaOCl for biomechanical preparation of root canals is a clinically acceptable and highly effective procedure, it must be used judiciously and with great caution to prevent it from reaching the periapex where it can elicit severe inflammatory reactions.

Original language	English (US)
Pages (from-to)	525-528
Number of pages	4
Journal	Journal of endodontics
Volume	11
Issue number	12
DOIs	https://doi.org/10.1016/S0099-2399(85)80197-7
State	Published - Dec 1985

ASJC Scopus subject areas

General Dentistry

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10.1016/S0099-2399(85)80197-7

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title = "Cytotoxic effects of NaOCl on vital tissue",

abstract = "The cytotoxicity of various dilutions of sodium hypochlorite was evaluated using three independent biological models. Dilutions as low as 1:1000 caused complete hemolysis of RBC's in vitro. Undiluted and 1:10 dilutions produced moderate to severe irritation to rabbit eyes which healed after 24 to 48 h. Intradermal injections of undiluted, 1:1, 1:2, and 1:4 dilutions of NaOCl produced skin ulcerations following intradermal injections. Although the use of 5% NaOCl for biomechanical preparation of root canals is a clinically acceptable and highly effective procedure, it must be used judiciously and with great caution to prevent it from reaching the periapex where it can elicit severe inflammatory reactions.",

author = "Pashley, {E. L.} and Birdsong, {N. L.} and K. Bowman and Pashley, {D. H.}",

note = "Funding Information: This work was supported, in part, by Grant DE 06427 from the National Institute of Dental Research.",

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doi = "10.1016/S0099-2399(85)80197-7",

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T1 - Cytotoxic effects of NaOCl on vital tissue

AU - Pashley, E. L.

AU - Birdsong, N. L.

AU - Bowman, K.

AU - Pashley, D. H.

N1 - Funding Information: This work was supported, in part, by Grant DE 06427 from the National Institute of Dental Research.

PY - 1985/12

Y1 - 1985/12

N2 - The cytotoxicity of various dilutions of sodium hypochlorite was evaluated using three independent biological models. Dilutions as low as 1:1000 caused complete hemolysis of RBC's in vitro. Undiluted and 1:10 dilutions produced moderate to severe irritation to rabbit eyes which healed after 24 to 48 h. Intradermal injections of undiluted, 1:1, 1:2, and 1:4 dilutions of NaOCl produced skin ulcerations following intradermal injections. Although the use of 5% NaOCl for biomechanical preparation of root canals is a clinically acceptable and highly effective procedure, it must be used judiciously and with great caution to prevent it from reaching the periapex where it can elicit severe inflammatory reactions.

AB - The cytotoxicity of various dilutions of sodium hypochlorite was evaluated using three independent biological models. Dilutions as low as 1:1000 caused complete hemolysis of RBC's in vitro. Undiluted and 1:10 dilutions produced moderate to severe irritation to rabbit eyes which healed after 24 to 48 h. Intradermal injections of undiluted, 1:1, 1:2, and 1:4 dilutions of NaOCl produced skin ulcerations following intradermal injections. Although the use of 5% NaOCl for biomechanical preparation of root canals is a clinically acceptable and highly effective procedure, it must be used judiciously and with great caution to prevent it from reaching the periapex where it can elicit severe inflammatory reactions.

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Cytotoxic effects of NaOCl on vital tissue

Abstract

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