TY - JOUR
T1 - Day-to-day deviations in sleep parameters and biological aging
T2 - Findings from the NHANES 2011-2014
AU - Wang, Xiaoling
AU - Xu, Yanyan
AU - Li, Xinyue
AU - Mansuri, Asifhusen
AU - McCall, William V.
AU - Liu, Yutao
AU - Su, Shaoyong
N1 - Publisher Copyright:
© 2023 National Sleep Foundation
PY - 2023/12
Y1 - 2023/12
N2 - Objectives: The majority of the previous research has focused on the impact of average sleep parameters on longevity. In this study, we aimed to investigate the associations of day-to-day deviations in sleep parameters with biological ages among 6052 adults participating in the 2011-2014 waves of the US National Health and Nutrition Examination Survey. Methods: Sleep parameters, including sleep duration, efficiency, midpoint, and day-to-day deviations in sleep parameters, including standard deviation of sleep duration (sleep variability), standard deviation of sleep midpoint (sleep irregularity), catch-up sleep, and social jetlag, were obtained from 4 to 7 days of 24-h accelerometer recording. We used physiological data to compute measurements of biological aging according to 3 published algorithms: PhenoAge, Klemera-Doubal method Biological Age, and homeostatic dysregulation. Results: After adjustment of multiple covariates, we observed that all parameters of day-to-day deviations in sleep were significantly associated with biological aging with larger sleep variability, larger sleep irregularity, more catch-up sleep, and more social jetlag linked with more advanced biological aging. The significant associations of sleep irregularity, catch-up sleep, and social jetlag with biological aging indices remained even after adjustment for sleep duration, efficiency, and midpoint. Conclusion: In this study, we found that day-to-day deviations in sleep parameters are independently associated with biological aging in US general population. Since day-to-day deviation in sleep is a modifiable behavioral factor, our finding suggests that intervention aiming at increasing regularity in sleep patterns may be a novel approach for extending a healthy life span.
AB - Objectives: The majority of the previous research has focused on the impact of average sleep parameters on longevity. In this study, we aimed to investigate the associations of day-to-day deviations in sleep parameters with biological ages among 6052 adults participating in the 2011-2014 waves of the US National Health and Nutrition Examination Survey. Methods: Sleep parameters, including sleep duration, efficiency, midpoint, and day-to-day deviations in sleep parameters, including standard deviation of sleep duration (sleep variability), standard deviation of sleep midpoint (sleep irregularity), catch-up sleep, and social jetlag, were obtained from 4 to 7 days of 24-h accelerometer recording. We used physiological data to compute measurements of biological aging according to 3 published algorithms: PhenoAge, Klemera-Doubal method Biological Age, and homeostatic dysregulation. Results: After adjustment of multiple covariates, we observed that all parameters of day-to-day deviations in sleep were significantly associated with biological aging with larger sleep variability, larger sleep irregularity, more catch-up sleep, and more social jetlag linked with more advanced biological aging. The significant associations of sleep irregularity, catch-up sleep, and social jetlag with biological aging indices remained even after adjustment for sleep duration, efficiency, and midpoint. Conclusion: In this study, we found that day-to-day deviations in sleep parameters are independently associated with biological aging in US general population. Since day-to-day deviation in sleep is a modifiable behavioral factor, our finding suggests that intervention aiming at increasing regularity in sleep patterns may be a novel approach for extending a healthy life span.
KW - Biological aging
KW - Circadian rhythm
KW - NHANES
KW - Sleep variability
UR - http://www.scopus.com/inward/record.url?scp=85171547341&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85171547341&partnerID=8YFLogxK
U2 - 10.1016/j.sleh.2023.07.018
DO - 10.1016/j.sleh.2023.07.018
M3 - Article
C2 - 37648648
AN - SCOPUS:85171547341
SN - 2352-7218
VL - 9
SP - 940
EP - 946
JO - Sleep Health
JF - Sleep Health
IS - 6
ER -