DCC-dependent phospholipase C signaling in netrin-1-induced neurite elongation

Yi Xie, Yan Hong, Xiao Yue Ma, Xiu Rong Ren, Susan Ackerman, Lin Mei, Wen Cheng Xiong

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Netrins, a family of secreted molecules, play important roles in axon pathfinding during nervous system development. Although phosphatidylinositol signaling has been implicated in this event, how netrin-1 regulates phosphatidylinositol signaling remains poorly understood. Here we provide evidence that netrin-1 stimulates phosphatidylinositol bisphosphate hydrolysis in cortical neurons. This event appears to be mediated by DCC (deleted in colorectal cancer), but not neogenin or Unc5h2. Netrin-1 induces phospholipase Cγ (PLCγ) tyrosine phosphorylation. Inhibition of PLC activity attenuates netrin-1-induced cortical neurite outgrowth. These results suggest that netrin-1 regulates phosphatidylinositol turnover and demonstrate a crucial role of PLC signaling in netrin-1-induced neurite elongation.

Original languageEnglish (US)
Pages (from-to)2605-2611
Number of pages7
JournalJournal of Biological Chemistry
Issue number5
StatePublished - Feb 3 2006
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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