Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

Clodagh Towns; Madeleine Richer; Simona Jasaityte; Eleanor J. Stafford; Julie Joubert; Tarek Antar; Alejandro Martinez-Carrasco; Mary B. Makarious; Bradford Casey; Dan Vitale; Kristin Levine; Hampton Leonard; Caroline B. Pantazis; Laurel A. Screven; Dena G. Hernandez; Claire E. Wegel; Justin Solle; Mike A. Nalls; Cornelis Blauwendraat; Andrew B. Singleton; Manuela M.X. Tan; Hirotaka Iwaki; Huw R. Morris; Emilia M. Gatto; Marcelo Kauffman; Samson Khachatryan; Zaruhi Tavadyan; Claire E. Shepherd; Julie Hunter; Kishore Kumar; Melina Ellis; Miguel E. Rentería; Sulev Koks; Alexander Zimprich; Artur F. Schumacher-Schuh; Carlos Rieder; Paula Saffie Awad; Vitor Tumas; Sarah Camargos; Edward A. Fon; Oury Monchi; Ted Fon; Benjamin Pizarro Galleguillos; Marcelo Miranda; Maria Leonor Bustamante; Patricio Olguin; Pedro Chana; Beisha Tang; Huifang Shang; Jifeng Guo; Piu Chan; Wei Luo; Gonzalo Arboleda; Jorge Orozco; Marlene Jimenez del Rio; Alvaro Hernandez; Mohamed Salama; Walaa A. Kamel; Yared Z. Zewde; Alexis Brice; Jean Christophe Corvol; Ana Westenberger; Anastasia Illarionova; Brit Mollenhauer; Christine Klein; Eva Juliane Vollstedt; Franziska Hopfner; Günter Höglinger; Harutyun Madoev; Joanne Trinh; Johanna Junker; Katja Lohmann; Lara M. Lange; Manu Sharma; Sergiu Groppa; Thomas Gasser; Zih Hua Fang; Albert Akpalu; Georgia Xiromerisiou; Georgios Hadjigorgiou; Ioannis Dagklis; Ioannis Tarnanas; Leonidas Stefanis; Maria Stamelou; Efthymios Dadiotis; Alex Medina; Germaine Hiu Fai Chan; Nancy Ip; Nelson Yuk Fai Cheung; Phillip Chan; Xiaopu Zhou; Asha Kishore; Divya Kp; Pramod Pal; Prashanth Lingappa Kukkle; Roopa Rajan; Rupam Borgohain; Mehri Salari; Andrea Quattrone; Enza Maria Valente; Lucilla Parnetti; Micol Avenali; Tommaso Schirinzi; Manabu Funayama; Nobutaka Hattori; Tomotaka Shiraishi; Altynay Karimova; Gulnaz Kaishibayeva; Cholpon Shambetova; Rejko Krüger; Ai Huey Tan; Azlina Ahmad-Annuar; Mohamed Ibrahim Norlinah; Nor Azian Abdul Murad; Shahrul Azmin; Shen Yang Lim; Wael Mohamed; Yi Wen Tay; Daniel Martinez-Ramirez; Mayela Rodriguez-Violante; Paula Reyes-Pérez; Bayasgalan Tserensodnom; Rajeev Ojha; Tim J. Anderson; Toni L. Pitcher; Arinola Sanyaolu; Njideka Okubadejo; Oluwadamilola Ojo; Jan O. Aasly; Lasse Pihlstrøm; Manuela Tan; Shoaib Ur-Rehman; Mario Cornejo-Olivas; Maria Leila Doquenia; Raymond Rosales; Angel Vinuela; Elena Iakovenko; Bashayer Al Mubarak; Muhammad Umair; Eng King Tan; Jia Nee Foo; Ferzana Amod; Jonathan Carr; Soraya Bardien; Beomseok Jeon; Yun Joong Kim; Esther Cubo; Ignacio Alvarez; Janet Hoenicka; Katrin Beyer; Maria Teresa Periñan; Pau Pastor; Sarah El-Sadig; Christiane Zweier; Paul Krack; Chin Hsien Lin; Hsiu Chuan Wu; Pin Jui Kung; Ruey Meei Wu; Yihru Wu; Rim Amouri; Samia Ben Sassi; A. Nazlı Başak; Gencer Genc; Özgür Öztop Çakmak; Sibel Ertan; Alastair Noyce; Anette Schrag; Anthony Schapira; Camille Carroll; Claire Bale; Donald Grosset; Henry Houlden; John Hardy; Kin Ying Mok; Mie Rizig; Nicholas Wood; Nigel Williams; Olaitan Okunoye; Patrick Alfryn Lewis; Rauan Kaiyrzhanov; Rimona Weil; Seth Love; Simon Stott; Simona Jasaitye; Sumit Dey; Vida Obese; Alberto Espay; Alyssa O’Grady; Andrew K. Sobering; Bernadette Siddiqi; Brian Fiske; Cabell Jonas; Carlos Cruchaga; Charisse Comart; Claire Wegel; Deborah Hall; Dena Hernandez; Ejaz Shiamim; Ekemini Riley; Faraz Faghri; Geidy E. Serrano; Honglei Chen; Ignacio F. Mata; Ignacio Juan Keller Sarmiento; Jared Williamson; Jonggeol Jeff Kim; Joseph Jankovic; Joshua Shulman; Justin C. Solle; Kaileigh Murphy; Karen Nuytemans; Karl Kieburtz; Katerina Markopoulou; Kenneth Marek; Kristin S. Levine; Lana M. Chahine; Laura Ibanez; Laurel Screven; Lauren Ruffrage; Lisa Shulman; Luca Marsili; Maggie Kuhl; Marissa Dean; Mathew Koretsky; Megan J. Puckelwartz; Miguel Inca-Martinez; Naomi Louie; Niccolò Emanuele Mencacci; Roger Albin; Roy Alcalay; Ruth Walker; Sara Bandres-Ciga; Sohini Chowdhury; Sonya Dumanis; Steven Lubbe; Tao Xie; Tatiana Foroud; Thomas Beach; Todd Sherer; Yeajin Song; Duan Nguyen; Toan Nguyen; Masharip Atadzhanov

doi:10.1038/s41531-023-00533-w

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

Clodagh Towns, Madeleine Richer, Simona Jasaityte, Eleanor J. Stafford, Julie Joubert, Tarek Antar, Alejandro Martinez-Carrasco, Mary B. Makarious, Bradford Casey, Dan Vitale, Kristin Levine, Hampton Leonard, Caroline B. Pantazis, Laurel A. Screven, Dena G. Hernandez, Claire E. Wegel, Justin Solle, Mike A. Nalls, Cornelis Blauwendraat, Andrew B. SingletonManuela M.X. Tan, Hirotaka Iwaki, Huw R. Morris, Emilia M. Gatto, Marcelo Kauffman, Samson Khachatryan, Zaruhi Tavadyan, Claire E. Shepherd, Julie Hunter, Kishore Kumar, Melina Ellis, Miguel E. Rentería, Sulev Koks, Alexander Zimprich, Artur F. Schumacher-Schuh, Carlos Rieder, Paula Saffie Awad, Vitor Tumas, Sarah Camargos, Edward A. Fon, Oury Monchi, Ted Fon, Benjamin Pizarro Galleguillos, Marcelo Miranda, Maria Leonor Bustamante, Patricio Olguin, Pedro Chana, Beisha Tang, Huifang Shang, Jifeng Guo, Piu Chan, Wei Luo, Gonzalo Arboleda, Jorge Orozco, Marlene Jimenez del Rio, Alvaro Hernandez, Mohamed Salama, Walaa A. Kamel, Yared Z. Zewde, Alexis Brice, Jean Christophe Corvol, Ana Westenberger, Anastasia Illarionova, Brit Mollenhauer, Christine Klein, Eva Juliane Vollstedt, Franziska Hopfner, Günter Höglinger, Harutyun Madoev, Joanne Trinh, Johanna Junker, Katja Lohmann, Lara M. Lange, Manu Sharma, Sergiu Groppa, Thomas Gasser, Zih Hua Fang, Albert Akpalu, Georgia Xiromerisiou, Georgios Hadjigorgiou, Ioannis Dagklis, Ioannis Tarnanas, Leonidas Stefanis, Maria Stamelou, Efthymios Dadiotis, Alex Medina, Germaine Hiu Fai Chan, Nancy Ip, Nelson Yuk Fai Cheung, Phillip Chan, Xiaopu Zhou, Asha Kishore, Divya Kp, Pramod Pal, Prashanth Lingappa Kukkle, Roopa Rajan, Rupam Borgohain, Mehri Salari, Andrea Quattrone, Enza Maria Valente, Lucilla Parnetti, Micol Avenali, Tommaso Schirinzi, Manabu Funayama, Nobutaka Hattori, Tomotaka Shiraishi, Altynay Karimova, Gulnaz Kaishibayeva, Cholpon Shambetova, Rejko Krüger, Ai Huey Tan, Azlina Ahmad-Annuar, Mohamed Ibrahim Norlinah, Nor Azian Abdul Murad, Shahrul Azmin, Shen Yang Lim, Wael Mohamed, Yi Wen Tay, Daniel Martinez-Ramirez, Mayela Rodriguez-Violante, Paula Reyes-Pérez, Bayasgalan Tserensodnom, Rajeev Ojha, Tim J. Anderson, Toni L. Pitcher, Arinola Sanyaolu, Njideka Okubadejo, Oluwadamilola Ojo, Jan O. Aasly, Lasse Pihlstrøm, Manuela Tan, Shoaib Ur-Rehman, Mario Cornejo-Olivas, Maria Leila Doquenia, Raymond Rosales, Angel Vinuela, Elena Iakovenko, Bashayer Al Mubarak, Muhammad Umair, Eng King Tan, Jia Nee Foo, Ferzana Amod, Jonathan Carr, Soraya Bardien, Beomseok Jeon, Yun Joong Kim, Esther Cubo, Ignacio Alvarez, Janet Hoenicka, Katrin Beyer, Maria Teresa Periñan, Pau Pastor, Sarah El-Sadig, Christiane Zweier, Paul Krack, Chin Hsien Lin, Hsiu Chuan Wu, Pin Jui Kung, Ruey Meei Wu, Yihru Wu, Rim Amouri, Samia Ben Sassi, A. Nazlı Başak, Gencer Genc, Özgür Öztop Çakmak, Sibel Ertan, Alastair Noyce, Anette Schrag, Anthony Schapira, Camille Carroll, Claire Bale, Donald Grosset, Henry Houlden, John Hardy, Kin Ying Mok, Mie Rizig, Nicholas Wood, Nigel Williams, Olaitan Okunoye, Patrick Alfryn Lewis, Rauan Kaiyrzhanov, Rimona Weil, Seth Love, Simon Stott, Simona Jasaitye, Sumit Dey, Vida Obese, Alberto Espay, Alyssa O’Grady, Andrew K. Sobering, Bernadette Siddiqi, Brian Fiske, Cabell Jonas, Carlos Cruchaga, Charisse Comart, Claire Wegel, Deborah Hall, Dena Hernandez, Ejaz Shiamim, Ekemini Riley, Faraz Faghri, Geidy E. Serrano, Honglei Chen, Ignacio F. Mata, Ignacio Juan Keller Sarmiento, Jared Williamson, Jonggeol Jeff Kim, Joseph Jankovic, Joshua Shulman, Justin C. Solle, Kaileigh Murphy, Karen Nuytemans, Karl Kieburtz, Katerina Markopoulou, Kenneth Marek, Kristin S. Levine, Lana M. Chahine, Laura Ibanez, Laurel Screven, Lauren Ruffrage, Lisa Shulman, Luca Marsili, Maggie Kuhl, Marissa Dean, Mathew Koretsky, Megan J. Puckelwartz, Miguel Inca-Martinez, Naomi Louie, Niccolò Emanuele Mencacci, Roger Albin, Roy Alcalay, Ruth Walker, Sara Bandres-Ciga, Sohini Chowdhury, Sonya Dumanis, Steven Lubbe, Tao Xie, Tatiana Foroud, Thomas Beach, Todd Sherer, Yeajin Song, Duan Nguyen, Toan Nguyen, Masharip Atadzhanov

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.

Original language	English (US)
Article number	131
Journal	npj Parkinson's Disease
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41531-023-00533-w
State	Published - Dec 2023
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience

Access to Document

10.1038/s41531-023-00533-w

Cite this

Towns, C., Richer, M., Jasaityte, S., Stafford, E. J., Joubert, J., Antar, T., Martinez-Carrasco, A., Makarious, M. B., Casey, B., Vitale, D., Levine, K., Leonard, H., Pantazis, C. B., Screven, L. A., Hernandez, D. G., Wegel, C. E., Solle, J., Nalls, M. A., Blauwendraat, C., ... Atadzhanov, M. (2023). Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2). npj Parkinson's Disease, 9(1), Article 131. https://doi.org/10.1038/s41531-023-00533-w

Towns, C, Richer, M, Jasaityte, S, Stafford, EJ, Joubert, J, Antar, T, Martinez-Carrasco, A, Makarious, MB, Casey, B, Vitale, D, Levine, K, Leonard, H, Pantazis, CB, Screven, LA, Hernandez, DG, Wegel, CE, Solle, J, Nalls, MA, Blauwendraat, C, Singleton, AB, Tan, MMX, Iwaki, H, Morris, HR, Gatto, EM, Kauffman, M, Khachatryan, S, Tavadyan, Z, Shepherd, CE, Hunter, J, Kumar, K, Ellis, M, Rentería, ME, Koks, S, Zimprich, A, Schumacher-Schuh, AF, Rieder, C, Awad, PS, Tumas, V, Camargos, S, Fon, EA, Monchi, O, Fon, T, Galleguillos, BP, Miranda, M, Bustamante, ML, Olguin, P, Chana, P, Tang, B, Shang, H, Guo, J, Chan, P, Luo, W, Arboleda, G, Orozco, J, del Rio, MJ, Hernandez, A, Salama, M, Kamel, WA, Zewde, YZ, Brice, A, Corvol, JC, Westenberger, A, Illarionova, A, Mollenhauer, B, Klein, C, Vollstedt, EJ, Hopfner, F, Höglinger, G, Madoev, H, Trinh, J, Junker, J, Lohmann, K, Lange, LM, Sharma, M, Groppa, S, Gasser, T, Fang, ZH, Akpalu, A, Xiromerisiou, G, Hadjigorgiou, G, Dagklis, I, Tarnanas, I, Stefanis, L, Stamelou, M, Dadiotis, E, Medina, A, Chan, GHF, Ip, N, Cheung, NYF, Chan, P, Zhou, X, Kishore, A, Kp, D, Pal, P, Kukkle, PL, Rajan, R, Borgohain, R, Salari, M, Quattrone, A, Valente, EM, Parnetti, L, Avenali, M, Schirinzi, T, Funayama, M, Hattori, N, Shiraishi, T, Karimova, A, Kaishibayeva, G, Shambetova, C, Krüger, R, Tan, AH, Ahmad-Annuar, A, Norlinah, MI, Murad, NAA, Azmin, S, Lim, SY, Mohamed, W, Tay, YW, Martinez-Ramirez, D, Rodriguez-Violante, M, Reyes-Pérez, P, Tserensodnom, B, Ojha, R, Anderson, TJ, Pitcher, TL, Sanyaolu, A, Okubadejo, N, Ojo, O, Aasly, JO, Pihlstrøm, L, Tan, M, Ur-Rehman, S, Cornejo-Olivas, M, Doquenia, ML, Rosales, R, Vinuela, A, Iakovenko, E, Mubarak, BA, Umair, M, Tan, EK, Foo, JN, Amod, F, Carr, J, Bardien, S, Jeon, B, Kim, YJ, Cubo, E, Alvarez, I, Hoenicka, J, Beyer, K, Periñan, MT, Pastor, P, El-Sadig, S, Zweier, C, Krack, P, Lin, CH, Wu, HC, Kung, PJ, Wu, RM, Wu, Y, Amouri, R, Sassi, SB, Başak, AN, Genc, G, Çakmak, ÖÖ, Ertan, S, Noyce, A, Schrag, A, Schapira, A, Carroll, C, Bale, C, Grosset, D, Houlden, H, Hardy, J, Mok, KY, Rizig, M, Wood, N, Williams, N, Okunoye, O, Lewis, PA, Kaiyrzhanov, R, Weil, R, Love, S, Stott, S, Jasaitye, S, Dey, S, Obese, V, Espay, A, O’Grady, A, Sobering, AK, Siddiqi, B, Fiske, B, Jonas, C, Cruchaga, C, Comart, C, Wegel, C, Hall, D, Hernandez, D, Shiamim, E, Riley, E, Faghri, F, Serrano, GE, Chen, H, Mata, IF, Sarmiento, IJK, Williamson, J, Kim, JJ, Jankovic, J, Shulman, J, Solle, JC, Murphy, K, Nuytemans, K, Kieburtz, K, Markopoulou, K, Marek, K, Levine, KS, Chahine, LM, Ibanez, L, Screven, L, Ruffrage, L, Shulman, L, Marsili, L, Kuhl, M, Dean, M, Koretsky, M, Puckelwartz, MJ, Inca-Martinez, M, Louie, N, Mencacci, NE, Albin, R, Alcalay, R, Walker, R, Bandres-Ciga, S, Chowdhury, S, Dumanis, S, Lubbe, S, Xie, T, Foroud, T, Beach, T, Sherer, T, Song, Y, Nguyen, D, Nguyen, T & Atadzhanov, M 2023, 'Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)', npj Parkinson's Disease, vol. 9, no. 1, 131. https://doi.org/10.1038/s41531-023-00533-w

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title = "Defining the causes of sporadic Parkinson{\textquoteright}s disease in the global Parkinson{\textquoteright}s genetics program (GP2)",

abstract = "The Global Parkinson{\textquoteright}s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.",

author = "Clodagh Towns and Madeleine Richer and Simona Jasaityte and Stafford, {Eleanor J.} and Julie Joubert and Tarek Antar and Alejandro Martinez-Carrasco and Makarious, {Mary B.} and Bradford Casey and Dan Vitale and Kristin Levine and Hampton Leonard and Pantazis, {Caroline B.} and Screven, {Laurel A.} and Hernandez, {Dena G.} and Wegel, {Claire E.} and Justin Solle and Nalls, {Mike A.} and Cornelis Blauwendraat and Singleton, {Andrew B.} and Tan, {Manuela M.X.} and Hirotaka Iwaki and Morris, {Huw R.} and Gatto, {Emilia M.} and Marcelo Kauffman and Samson Khachatryan and Zaruhi Tavadyan and Shepherd, {Claire E.} and Julie Hunter and Kishore Kumar and Melina Ellis and Renter{\'i}a, {Miguel E.} and Sulev Koks and Alexander Zimprich and Schumacher-Schuh, {Artur F.} and Carlos Rieder and Awad, {Paula Saffie} and Vitor Tumas and Sarah Camargos and Fon, {Edward A.} and Oury Monchi and Ted Fon and Galleguillos, {Benjamin Pizarro} and Marcelo Miranda and Bustamante, {Maria Leonor} and Patricio Olguin and Pedro Chana and Beisha Tang and Huifang Shang and Jifeng Guo and Piu Chan and Wei Luo and Gonzalo Arboleda and Jorge Orozco and {del Rio}, {Marlene Jimenez} and Alvaro Hernandez and Mohamed Salama and Kamel, {Walaa A.} and Zewde, {Yared Z.} and Alexis Brice and Corvol, {Jean Christophe} and Ana Westenberger and Anastasia Illarionova and Brit Mollenhauer and Christine Klein and Vollstedt, {Eva Juliane} and Franziska Hopfner and G{\"u}nter H{\"o}glinger and Harutyun Madoev and Joanne Trinh and Johanna Junker and Katja Lohmann and Lange, {Lara M.} and Manu Sharma and Sergiu Groppa and Thomas Gasser and Fang, {Zih Hua} and Albert Akpalu and Georgia Xiromerisiou and Georgios Hadjigorgiou and Ioannis Dagklis and Ioannis Tarnanas and Leonidas Stefanis and Maria Stamelou and Efthymios Dadiotis and Alex Medina and Chan, {Germaine Hiu Fai} and Nancy Ip and Cheung, {Nelson Yuk Fai} and Phillip Chan and Xiaopu Zhou and Asha Kishore and Divya Kp and Pramod Pal and Kukkle, {Prashanth Lingappa} and Roopa Rajan and Rupam Borgohain and Mehri Salari and Andrea Quattrone and Valente, {Enza Maria} and Lucilla Parnetti and Micol Avenali and Tommaso Schirinzi and Manabu Funayama and Nobutaka Hattori and Tomotaka Shiraishi and Altynay Karimova and Gulnaz Kaishibayeva and Cholpon Shambetova and Rejko Kr{\"u}ger and Tan, {Ai Huey} and Azlina Ahmad-Annuar and Norlinah, {Mohamed Ibrahim} and Murad, {Nor Azian Abdul} and Shahrul Azmin and Lim, {Shen Yang} and Wael Mohamed and Tay, {Yi Wen} and Daniel Martinez-Ramirez and Mayela Rodriguez-Violante and Paula Reyes-P{\'e}rez and Bayasgalan Tserensodnom and Rajeev Ojha and Anderson, {Tim J.} and Pitcher, {Toni L.} and Arinola Sanyaolu and Njideka Okubadejo and Oluwadamilola Ojo and Aasly, {Jan O.} and Lasse Pihlstr{\o}m and Manuela Tan and Shoaib Ur-Rehman and Mario Cornejo-Olivas and Doquenia, {Maria Leila} and Raymond Rosales and Angel Vinuela and Elena Iakovenko and Mubarak, {Bashayer Al} and Muhammad Umair and Tan, {Eng King} and Foo, {Jia Nee} and Ferzana Amod and Jonathan Carr and Soraya Bardien and Beomseok Jeon and Kim, {Yun Joong} and Esther Cubo and Ignacio Alvarez and Janet Hoenicka and Katrin Beyer and Peri{\~n}an, {Maria Teresa} and Pau Pastor and Sarah El-Sadig and Christiane Zweier and Paul Krack and Lin, {Chin Hsien} and Wu, {Hsiu Chuan} and Kung, {Pin Jui} and Wu, {Ruey Meei} and Yihru Wu and Rim Amouri and Sassi, {Samia Ben} and Ba{\c s}ak, {A. Nazlı} and Gencer Genc and {\c C}akmak, {{\"O}zg{\"u}r {\"O}ztop} and Sibel Ertan and Alastair Noyce and Anette Schrag and Anthony Schapira and Camille Carroll and Claire Bale and Donald Grosset and Henry Houlden and John Hardy and Mok, {Kin Ying} and Mie Rizig and Nicholas Wood and Nigel Williams and Olaitan Okunoye and Lewis, {Patrick Alfryn} and Rauan Kaiyrzhanov and Rimona Weil and Seth Love and Simon Stott and Simona Jasaitye and Sumit Dey and Vida Obese and Alberto Espay and Alyssa O{\textquoteright}Grady and Sobering, {Andrew K.} and Bernadette Siddiqi and Brian Fiske and Cabell Jonas and Carlos Cruchaga and Charisse Comart and Claire Wegel and Deborah Hall and Dena Hernandez and Ejaz Shiamim and Ekemini Riley and Faraz Faghri and Serrano, {Geidy E.} and Honglei Chen and Mata, {Ignacio F.} and Sarmiento, {Ignacio Juan Keller} and Jared Williamson and Kim, {Jonggeol Jeff} and Joseph Jankovic and Joshua Shulman and Solle, {Justin C.} and Kaileigh Murphy and Karen Nuytemans and Karl Kieburtz and Katerina Markopoulou and Kenneth Marek and Levine, {Kristin S.} and Chahine, {Lana M.} and Laura Ibanez and Laurel Screven and Lauren Ruffrage and Lisa Shulman and Luca Marsili and Maggie Kuhl and Marissa Dean and Mathew Koretsky and Puckelwartz, {Megan J.} and Miguel Inca-Martinez and Naomi Louie and Mencacci, {Niccol{\`o} Emanuele} and Roger Albin and Roy Alcalay and Ruth Walker and Sara Bandres-Ciga and Sohini Chowdhury and Sonya Dumanis and Steven Lubbe and Tao Xie and Tatiana Foroud and Thomas Beach and Todd Sherer and Yeajin Song and Duan Nguyen and Toan Nguyen and Masharip Atadzhanov",

note = "Publisher Copyright: {\textcopyright} 2023, Springer Nature Limited.",

year = "2023",

month = dec,

doi = "10.1038/s41531-023-00533-w",

language = "English (US)",

volume = "9",

journal = "npj Parkinson's Disease",

issn = "2373-8057",

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number = "1",

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TY - JOUR

T1 - Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

AU - Towns, Clodagh

AU - Richer, Madeleine

AU - Jasaityte, Simona

AU - Stafford, Eleanor J.

AU - Joubert, Julie

AU - Antar, Tarek

AU - Martinez-Carrasco, Alejandro

AU - Makarious, Mary B.

AU - Casey, Bradford

AU - Vitale, Dan

AU - Levine, Kristin

AU - Leonard, Hampton

AU - Pantazis, Caroline B.

AU - Screven, Laurel A.

AU - Hernandez, Dena G.

AU - Wegel, Claire E.

AU - Solle, Justin

AU - Nalls, Mike A.

AU - Blauwendraat, Cornelis

AU - Singleton, Andrew B.

AU - Tan, Manuela M.X.

AU - Iwaki, Hirotaka

AU - Morris, Huw R.

AU - Gatto, Emilia M.

AU - Kauffman, Marcelo

AU - Khachatryan, Samson

AU - Tavadyan, Zaruhi

AU - Shepherd, Claire E.

AU - Hunter, Julie

AU - Kumar, Kishore

AU - Ellis, Melina

AU - Rentería, Miguel E.

AU - Koks, Sulev

AU - Zimprich, Alexander

AU - Schumacher-Schuh, Artur F.

AU - Rieder, Carlos

AU - Awad, Paula Saffie

AU - Tumas, Vitor

AU - Camargos, Sarah

AU - Fon, Edward A.

AU - Monchi, Oury

AU - Fon, Ted

AU - Galleguillos, Benjamin Pizarro

AU - Miranda, Marcelo

AU - Bustamante, Maria Leonor

AU - Olguin, Patricio

AU - Chana, Pedro

AU - Tang, Beisha

AU - Shang, Huifang

AU - Guo, Jifeng

AU - Chan, Piu

AU - Luo, Wei

AU - Arboleda, Gonzalo

AU - Orozco, Jorge

AU - del Rio, Marlene Jimenez

AU - Hernandez, Alvaro

AU - Salama, Mohamed

AU - Kamel, Walaa A.

AU - Zewde, Yared Z.

AU - Brice, Alexis

AU - Corvol, Jean Christophe

AU - Westenberger, Ana

AU - Illarionova, Anastasia

AU - Mollenhauer, Brit

AU - Klein, Christine

AU - Vollstedt, Eva Juliane

AU - Hopfner, Franziska

AU - Höglinger, Günter

AU - Madoev, Harutyun

AU - Trinh, Joanne

AU - Junker, Johanna

AU - Lohmann, Katja

AU - Lange, Lara M.

AU - Sharma, Manu

AU - Groppa, Sergiu

AU - Gasser, Thomas

AU - Fang, Zih Hua

AU - Akpalu, Albert

AU - Xiromerisiou, Georgia

AU - Hadjigorgiou, Georgios

AU - Dagklis, Ioannis

AU - Tarnanas, Ioannis

AU - Stefanis, Leonidas

AU - Stamelou, Maria

AU - Dadiotis, Efthymios

AU - Medina, Alex

AU - Chan, Germaine Hiu Fai

AU - Ip, Nancy

AU - Cheung, Nelson Yuk Fai

AU - Chan, Phillip

AU - Zhou, Xiaopu

AU - Kishore, Asha

AU - Kp, Divya

AU - Pal, Pramod

AU - Kukkle, Prashanth Lingappa

AU - Rajan, Roopa

AU - Borgohain, Rupam

AU - Salari, Mehri

AU - Quattrone, Andrea

AU - Valente, Enza Maria

AU - Parnetti, Lucilla

AU - Avenali, Micol

AU - Schirinzi, Tommaso

AU - Funayama, Manabu

AU - Hattori, Nobutaka

AU - Shiraishi, Tomotaka

AU - Karimova, Altynay

AU - Kaishibayeva, Gulnaz

AU - Shambetova, Cholpon

AU - Krüger, Rejko

AU - Tan, Ai Huey

AU - Ahmad-Annuar, Azlina

AU - Norlinah, Mohamed Ibrahim

AU - Murad, Nor Azian Abdul

AU - Azmin, Shahrul

AU - Lim, Shen Yang

AU - Mohamed, Wael

AU - Tay, Yi Wen

AU - Martinez-Ramirez, Daniel

AU - Rodriguez-Violante, Mayela

AU - Reyes-Pérez, Paula

AU - Tserensodnom, Bayasgalan

AU - Ojha, Rajeev

AU - Anderson, Tim J.

AU - Pitcher, Toni L.

AU - Sanyaolu, Arinola

AU - Okubadejo, Njideka

AU - Ojo, Oluwadamilola

AU - Aasly, Jan O.

AU - Pihlstrøm, Lasse

AU - Tan, Manuela

AU - Ur-Rehman, Shoaib

AU - Cornejo-Olivas, Mario

AU - Doquenia, Maria Leila

AU - Rosales, Raymond

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PY - 2023/12

Y1 - 2023/12

N2 - The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.

AB - The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.

UR - http://www.scopus.com/inward/record.url?scp=85170643330&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85170643330&partnerID=8YFLogxK

U2 - 10.1038/s41531-023-00533-w

DO - 10.1038/s41531-023-00533-w

M3 - Article

AN - SCOPUS:85170643330

SN - 2373-8057

VL - 9

JO - npj Parkinson's Disease

JF - npj Parkinson's Disease

IS - 1

M1 - 131

ER -

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

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